A recent international study led by researchers from the University of Southern California (USC) and the Queensland Institute of Medical Research (QIMR) in Australia has uncovered significant genetic variants that influence brain structure and volume, with potential implications for understanding and treating Parkinson’s disease and attention-deficit/hyperactivity disorder (ADHD). The findings,…

A study to be presented at the American College of Cardiology’s Annual Scientific Session found that young adults who were prescribed stimulant medications for attention deficit/hyperactivity disorder (ADHD) were more like to develop cardiomyopathy—a weakened heart muscle—compared with young adults who were not prescribed them. In particular, the study showed…

Results from a large study carried out in Sweden show that long-term use of attention-deficit/hyperactivity disorder (ADHD) medication can increase cardiovascular disease (CVD) risk. Zheng Chang, a group leader at the Karolinska Institutet in Stockholm, and colleagues found that for every year of ADHD medication use CVD risk increased by…

Researchers have identified 27 genetic risk loci for attention-deficit hyperactivity disorder (ADHD) and provided a window into how it relates to other psychiatric conditions. The genome-wide analyses revealed 21 new loci linked with the neurodevelopmental disorder and found that it was influenced by thousands of genetic variants. The vast majority…

Being genetically predisposed to attention-deficit/hyperactivity disorder (ADHD) could increase the risk of Alzheimer’s disease in later life, research suggests. The study revealed that well-established ADHD biomarkers were collectively associated with cognitive declines, particularly in memory, among previously unaffected older adults. Cognitive decline was most common in those displaying amyloid (A)β…

Results from a study led by Yale School of Medicine show that functional magnetic resonance imaging (fMRI) scans could help diagnose attention-deficit/hyperactivity disorder (ADHD) in children more effectively than current methods. Statistics suggest that ADHD is one of the most common neurodevelopmental disorders, impacting around six million under 18-year olds…

New research from investigators at the National Institutes of Health (NIH) has revealed differences in the gene activity in the brains of people identified as having attention deficit hyperactivity disorder (ADHD). The study, conducted by scientists at NIH’s National Human Genome Research Institute (NHGRI) found that people with ADHD had…

Researchers at the Children’s Hospital of Philadelphia’s (CHOP) Center for Applied Genomics (CAG) have developed an algorithm using existing electronic health records (EHRs) is able to distinguish patients with attention deficit/hyperactivity disorder (ADHD) alone from other related conditions. The researchers hope the new tool can be applied in broader clinical…

A new study led by researchers from the University of Michigan demonstrate that mice with a variant associated with Attention deficit hyperactivity disorder (ADHD) adopt an inattentive phenotype similar to that seen in humans. Results of the study, published in The Journal of Neuroscience, indicate that a variant (Val89) in the choline…

Research carried out at the Children’s Hospital of Philadelphia suggests that structural genetic variants linked to attention-deficit hyperactivity disorder (ADHD) vary considerably between African Americans and individuals of European origin. The scientists, led Hakon Hakonarson, M.D., Ph.D., a professor at the Perelman School of Medicine at the University of Pennsylvania…

People with autism or ADHD share certain rare mutations, according to researchers from iPSYCH in Denmark, the Broad Institute and Harvard. One of the most commonly shared types of mutations were those affecting the microtubule-associated protein 1A gene (MAP1A), which is involved in the formation of nerve cells. According to…

A genome-wide association study (GWAS) published this week confirms what the psychiatric community has theorized for decades—that attention deficit/hyperactivity disorder (ADHD) has a large genetic component. A collaborative, global research team has identified the first genetic variants that increase the risk of ADHD. Anita Thapar, Ph.D., professor in the division…

Jonathan D. Grinstein, PhD, the North American Editor of Inside Precision Medicine, hosts a new series called Behind the Breakthroughs that features the people shaping the future of medicine. With each episode, Jonathan gives listeners access to their motivational tales and visions for this emerging, game-changing field. For the first…

A large language model (LLM) can measure the quality of primary care and flag areas for improvement among children prescribed medication for attention deficit hyperactivity disorder (ADHD), using the vast quantities of information stored in clinical notes. The open-source LLaMA model, described in Pediatrics, was able to assess how closely…

A genetic predisposition to dyslexia may be associated with specific brain structures that could also predispose to several other conditions, according to a major study involving data from the UK Biobank and 23andMe. Brain structures involved in motor, language-related and visual functions were implicated in dyslexia, a condition that is…