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Mutated p53’s Role in Atherosclerosis Reinforced
New evidence shows mutations in p53 contribute to the development of atherosclerotic cardiovascular disease.
New Biomarkers for Atherosclerosis Found Using Digital Twins
Newly identified markers of atherosclerotic coronary artery disease (ASCAD) were pinpointed in a study using digital twins by G3 Therapeutics and Aitia.
Findings Suggest Mitochondrial DNA Could be Atherosclerosis Drug Target
Scientists have uncovered a link between mitochondria, inflammation, and two genes that normally help regulate blood cell growth—DNMT3A and TET2— that, when mutated, are associated with an increased risk of atherosclerosis.
Preventing Atherosclerosis by Inhibiting PERK
Blocking PERK in smooth muscle cells blocks and decreases buildup of atherosclerotic plaque in mouse models, according to a new study from researchers at UTHealth Houston.
Gene That Promotes Atherosclerosis Found
Researchers discovered that the gene—called SVEP1—makes a protein that drives the development of plaque in the arteries. In mice, animals missing one copy of SVEP1 had less plaque in the arteries than mice with both copies.
Facial Flushing Variant Linked with Blood Vessel Inflammation
Researchers have discovered why a gene variant that is linked with facial flushing after drinking alcohol may increase the risk of coronary artery disease.
New Details Highlight PCSK9’s Role in Cardiovascular Disease and Cancer
New insights from Canadian researchers help explain how the PCSK9 protein degrades low-density lipoprotein (LDL) and its role in atherosclerosis and cancer.
AI Generates In-Silico Marker That Predicts Heart Disease Risk
A digital marker for coronary artery disease has been developed by Mount Sinai researchers based on machine learning and clinical data from electronic health records.
Parkinson’s Medication Could Reduce Heart Disease in Type 1 Diabetes Population
Bromocriptine has the potential to slow down the development of cardiovascular abnormalities and disease in young people with type 1 diabetes.
New siRNA Therapy Significantly Reduces Cholesterol Levels in Patients with Cardiovascular Disease
Researchers successfully lower cholesterol levels in patients with cardiovascular disease using investigational drug Olpasiran.
