A recent study from investigators at the UCLA Health Jonsson Comprehensive Cancer Center has found that common treatments for breast cancer—chemotherapy, radiation, and surgery—may contribute to accelerated biological aging in survivors. The research, published in the Journal of the National Cancer Institute, demonstrates that markers of cellular aging such as…

Commercially available artificial intelligence (AI) algorithms that help radiologists immediately detect breast cancer at mammography screening can also highlight women who are at risk years before their eventual diagnosis, research indicates. The findings, reported in JAMA Network Open, could offer a pathway for personalized screening that may lead to the…

Owkin and AstraZeneca have partnered on an AI-powered tool to pre-screen for germline BRCA (gBRCA) in breast cancer, directly from digitized pathology slides. This tool aims to significantly accelerate and expand access to gBRCA testing that many patients may not be considered for. The solution is currently in development and…

Extended estrogen suppression in postmenopausal breast cancer does not increase patients’ risk of coronary artery calcification, as some prior studies had indicated, new evidence from an international collaboration shows. This finding helps address a key issue in treating this population  Aromatase inhibitors are a mainstay in treating hormone receptor-positive postmenopausal…

Researchers from the Mass General Brigham have revealed that Black women face a higher risk of dying from breast cancer than white women across all tumor subtypes. The meta-analysis, published in the Journal of Clinical Oncology, shows that Black women’s risk of death varies from 17% to 50% higher depending…

The U.S. Food and Drug Administration (FDA) has approved Novartis’ Kisqali (CDK4/6 inhibitor ribociclib) for patients with early breast cancer (EBC) at high risk of recurrence, including those with node-negative (N0) disease. Kisqali is one of Novartis’ top selling cancer drugs, bringing in over $1B per year now. This new…

A 10-year study from researchers at the Yale School of Medicine has demonstrated that use of digital breast tomosynthesis (DBT) increases breast cancer detection rates and significantly reduces the rate of advanced cancer than does the standard screening method of two-dimensional digital mammography. Mammography has long been considered the gold…

Researchers at the Dana-Farber Cancer Institute, reporting at the European Society of Medical Oncology Congress in Barcelona, say that an antibody-drug conjugate that delivers chemotherapy directly to the tumor site has shown “impressive” activity against HER2-positive breast cancer that has spread to the brain. The findings, according to the study…

To better guide breast cancer treatment, a team from the Tangshan People’s Hospital and collaborators built an immune score (IS) based on immune checkpoint inhibitor-related mRNAs and lncRNAs that classifies patients into high and low groups and assesses their survival outcomes.The team reports that the IS score accurately predicts the…

Researchers at Rockefeller University have uncovered a crucial link between sensory neurons and the metastasis of breast cancer. Published in Nature, their work reveals that sensory nerves within breast tumors secrete a neuropeptide that significantly promotes cancer growth and spread. This discovery suggests that targeting this neuro-cancer crosstalk may help…

A large Danish study led by Odense University suggests women who experience gestational diabetes are not at increased risk of breast cancer compared with the general population. Although gestational diabetes resolves after birth, women who have had the condition are known to be at higher risk of developing type 2…

Many breast cancer survivors eligible for genetic counseling and testing are not receiving it according to a new study from the University of Michigan (U-M) Health Rogel Cancer Center. This is increasingly important as cancer treatment and follow up are getting more complex as more new drugs are being introduced.…

Drexel University College of Medicine investigators have discovered two drug-like molecules that show early promise to shrink brain tumors caused by metastatic breast cancer. Their research in a mouse model, published in the journal Frontiers in Pharmacology, represents the first successful attempt to target a key metabolic enzyme in brain…

Taxanes are often used as chemotherapy for breast cancer, but they can cause side effects in the nervous system, such as foot pain. Researchers at Linköping University in Sweden have now developed a statistical tool that uses sequencing and other data to predict individual risk level for such side effects.…

A new AI image tool that selects high-risk women for magnetic resonance imaging (MRI) after negative mammography detects many missed breast cancers, interim findings from a clinical trial suggest. The AI-based system could help offset the extra costs of MRI that have prevented it from being included in national screening…