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Published on March 27, 2024
Researchers from the Antoni van Leeuwenhoek-Netherlands Cancer Institute (AVL) have shown that patients with breast cancer that has spread to the lymph nodes can avoid extensive lymph node removal if the largest node responds fully to primary systemic therapy. In a presentation to the 14th European Breast Cancer Conference, Annemiek…
Published on March 20, 2024
A genetic test developed at the University of California San Francisco (UCSF) can identify triple negative breast cancer patients who will and won’t respond to commonly used immunotherapies. Triple negative breast cancer accounts for up to 15% of all breast cancers and affects around 13 in 100,000 women in the…
Published on March 4, 2024
New data from the National Cancer Institute’s Molecular Analysis for Therapy Choice (NCI-MATCH) precision medicine clinical trial has shown in a Phase II study that the trastuzumab-pertuzumab combination therapy, already approved for the treatment of HER2-positive breast cancer, shrunk the tumors of several other cancer types. The findings warrant additional…
Published on February 15, 2024
Researchers at the Johns Hopkins Kimmel Cancer Center have unveiled a promising new treatment approach for advanced HER2-negative breast cancer, using a three-drug combination that significantly improved responses in patients suffering from the disease. The study, published in Nature Cancer, involved a combination of a histone deacetylase (HDAC) inhibitor, which…
Published on February 14, 2024
Groundbreaking research from the University of Florida and National Yang Ming Chiao Tung University in Taiwan has led to the development of a hand-held device that detects breast cancer biomarkers in saliva. The biosensor design, which uses widely available components such as glucose testing strips and the open-source hardware-software platform…
Published on January 31, 2024
Investigators at the University of Illinois Chicago (UIC) have developed new data that show a commonly ordered breast cancer biomarker test to help clinicians decide whether breast cancer patients should receive chemotherapy may be making bad recommendations for some Black women who take the test. The test, The Oncotype 21-gene…
Published on January 29, 2024
Research led by the University Illinois Chicago shows a common genetic test, used by clinicians to help decide on treatment for women with estrogen receptor (ER) positive breast cancer, is less accurate in Black women. The Oncotype DX 21-gene test creates a recurrence score that is designed to show which…
Published on January 25, 2024
Women who are diagnosed with ductal carcinoma in situ (DCIS) are around four times as likely to develop invasive breast cancer and to die from breast cancer than women in the general population, according to a study published by The BMJ this week. This increased risk lasted for at least…
Published on January 17, 2024
Researchers from the University of North Carolina have discovered that disrupting the cell’s innate immune response to DNA damage could be a mechanism of cancer resistance. In their paper in Nature, a team proposes that the protein MRE11 could serve as a key in activating the cGAS-STING pathway, which is…
Published on January 11, 2024
Researchers at the University of North Carolina School of Medicine have identified a crucial mechanism in the cGAS-STING pathway that could unlock new avenues for breast cancer prevention and treatment. Published in Nature, the study sheds light on how cancer cells avoid detection by the immune system, despite sustaining DNA…
Published on January 10, 2024
Researchers in England have shown that around one third of women with breast cancer choose not to undergo surgery at their closest hospital, with patient choice often based on the reputation of the hospital or surgeon rather than the quality of care. Women who were younger, without additional medical conditions,…
Published on January 3, 2024
SimBioSys, which specializes in spatial biophysics and artificial intelligence (AI), has recently entered into a strategic collaboration with Mayo Clinic to advance digital precision medicine solutions for breast cancer patients. The collaboration will develop cloud-based clinical software tools that will guide the decision-making process for early-stage breast cancer patients, covering…
Published on December 27, 2023
Needle biopsy is indispensable to the diagnosis, typing, and targeted treatment of breast cancer. A new study, however, indicates that the testing itself triggers a series of cell-level changes that promote the spread of the disease months later. The results are the first of their kind to suggest a mechanism…
Published on December 21, 2023
Researchers at Stanford University have identified a protein, known as ENPP1 that can act as an on/off switch controlling breast cancer cell’s ability to metastasize and resist immunotherapy. Despite the strides made in cancer immunotherapies, a significant hurdle remains: more than 80 percent of advanced breast cancers resist these promising…
Published on December 20, 2023
Researchers observed that cells that are present in cancerous brain cells but not in normal brain tissue—known as cancer-associated fibroblasts (CAFs)—secrete a protein that stimulates breast cancer cells in the brain to migrate and invade more widely. The excreted protein, fucosylated poliovirus receptor (PVF), was shown in mouse models to…