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Published on February 4, 2025
Nearly 700,000 women across the U.K. will take part in a world-leading trial to test how cutting-edge AI tools can be used to catch breast cancer cases earlier, the U.K.’s Department of Health and Social Care announced today. That department is a division of the U.K.’s National Institute for Health…
Published on February 3, 2025
A national study led by researchers at Houston Methodist has identified potential inhibitor drugs that could help treat metaplastic breast cancer (MpBC), a rare and highly aggressive form of the disease. The study, published in Nature Communications, indicates that a combination therapy of a phosphoinositide 3 kinase inhibitor (P13K) with…
Published on January 29, 2025
Malignant tumors such as breast, lung or prostate cancer can spread from the initial site of tumor growth to other parts of the body through the bloodstream. Such cells are called circulating tumor cells (CTCs), and the spreading process, called metastasis, is the leading cause of cancer-related death. A new…
Published on January 24, 2025
Researchers at the Medical University of Vienna have developed a novel combination immunotherapy that holds significant potential for treating topically accessible cancers like melanoma and breast cancer. By combining systemic administration of the tissue hormone interferon-I (IFN-I) with localized application of the TLR7/8 agonist imiquimod, the treatment not only eliminated…
Published on January 22, 2025
A novel drug candidate developed by researchers at the University of Illinois called ErSO-TFPy, has demonstrated the ability to completely eliminate breast cancer tumors in mice with a single dose. The new compound, detailed in a study published in ACS Central Science, offers the potential to be developed as a…
Published on January 16, 2025
Researchers at the Washington University School of Medicine (WashU Medicine) in St. Louis have identified a potential new use for a drug currently in clinical trials for breast cancer. Two studies published in Nature Communications and Blood Cancer Journal reveal that inhibiting the protein RSK1 can halt the progression of…
Published on January 15, 2025
The world’s largest study on the use of AI-guided mammography screening to date has shown that the technology increases the rate of breast cancer detection without negatively impacting the recall rate. The results, which are published in Nature Medicine, also highlight the potential of AI to reduce the workload of…
Published on January 7, 2025
Two radiologists independently reading mammograms for signs of cancer is good, but two radiologists plus an artificial intelligence (AI) system is even better, even when rolled out nationwide. An AI system called Vara MG increased breast cancer detection rates (BCDR) while maintaining recall rates in a standard practice called double…
Published on December 18, 2024
Memorial Sloan Kettering Cancer Center researchers have created a multimodal machine learning (ML) tool that can identify patients with metastatic breast cancer most likely to respond to CDK4/6 inhibitors based on clinicopathologic and genomic features. “There’s a huge need in clinic to identify patients who may or may not benefit…
Published on December 11, 2024
New data from the OlympiA clinical trial presented at the 2024 San Antonio Breast Cancer Symposium (SABCS) show that the PARP inhibitor olaparib (Lynparza) significantly improves survival in patients with high-risk, BRCA-positive, HER2-negative early breast cancer. The findings, after a median follow-up of 6.1 years, further support the drug’s use…
Published on November 20, 2024
A study from Johns Hopkins University, published in Biophotonics Discovery, examined how skin tone affects the accuracy of photoacoustic imaging (PAI), a technology gaining traction in breast cancer diagnostics, especially in situations where traditional mammography is insufficient. The study shows how image reconstruction methods and laser wavelengths influence the visibility…
Published on November 13, 2024
An investigational vaccine designed by researchers at the Washington University (WashU) School of Medicine to prevent tumor recurrence has shown promising results in a phase I trial among patients with triple-negative breast cancer (TNBC). The neoantigen DNA vaccine targets patient-specific cancer neoantigens—mutant proteins or amino acid sequences that arise from…
Published on November 13, 2024
A group of Korean researchers has determined that women under 45 who get hormone-receptor negative breast cancer are at higher risk of distant recurrence even several years after treatment. These researchers write, “Because young patients with hormone receptor–positive, ERBB2-negative breast cancer have a relatively long life expectancy, the cumulative risk…
Published on November 12, 2024
A groundbreaking study from Harvard Medical School researchers should change long-held beliefs about the BRCA1 gene and its role in breast cancer. Researchers have discovered that even a single defective copy of the BRCA1 gene can make breast cells more susceptible to cancer, without the need for a second genetic…
Published on October 30, 2024
Researchers from the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a computational method to assess which patients with metastatic triple-negative breast cancer could benefit from immunotherapy. The work, published in the Proceedings of the National Academy of Sciences, aims to develop a more…