To better guide breast cancer treatment, a team from the Tangshan People’s Hospital and collaborators built an immune score (IS) based on immune checkpoint inhibitor-related mRNAs and lncRNAs that classifies patients into high and low groups and assesses their survival outcomes.The team reports that the IS score accurately predicts the…

Researchers at Rockefeller University have uncovered a crucial link between sensory neurons and the metastasis of breast cancer. Published in Nature, their work reveals that sensory nerves within breast tumors secrete a neuropeptide that significantly promotes cancer growth and spread. This discovery suggests that targeting this neuro-cancer crosstalk may help…

A large Danish study led by Odense University suggests women who experience gestational diabetes are not at increased risk of breast cancer compared with the general population. Although gestational diabetes resolves after birth, women who have had the condition are known to be at higher risk of developing type 2…

Many breast cancer survivors eligible for genetic counseling and testing are not receiving it according to a new study from the University of Michigan (U-M) Health Rogel Cancer Center. This is increasingly important as cancer treatment and follow up are getting more complex as more new drugs are being introduced.…

Drexel University College of Medicine investigators have discovered two drug-like molecules that show early promise to shrink brain tumors caused by metastatic breast cancer. Their research in a mouse model, published in the journal Frontiers in Pharmacology, represents the first successful attempt to target a key metabolic enzyme in brain…

Taxanes are often used as chemotherapy for breast cancer, but they can cause side effects in the nervous system, such as foot pain. Researchers at Linköping University in Sweden have now developed a statistical tool that uses sequencing and other data to predict individual risk level for such side effects.…

A new AI image tool that selects high-risk women for magnetic resonance imaging (MRI) after negative mammography detects many missed breast cancers, interim findings from a clinical trial suggest. The AI-based system could help offset the extra costs of MRI that have prevented it from being included in national screening…

Real-time AI assistance led to much greater efficiency and lower cost, in a study by Dutch researchers of sentinel node biopsies for breast cancer. Sentinel lymph nodes (SNs) are the first lymph nodes to drain lymphatic flow from the tumor. Testing them can be a difficult and time-consuming process.  This…

Dana-Farber Cancer Institute investigators have found that a year of treatment with an antibody and chemotherapy drug conjugate is highly effective at preventing recurrence of HER2-positive breast cancer in patients with stage 1 disease. The Phase II ATEMPT clinical study, published in the Journal of Clinical Oncology, showed that 97%…

Researchers at the University of Copenhagen have shown that using a commercially available AI system can reduce the workload of radiologists by over 33% while improving the overall performance of breast cancer screenings. Mammography exams are routinely used for the early detection of breast cancer, which helps reduce the mortality…

Breakthrough cancer drug Enhertu (trastuzumab deruxtecan) appears to have scored another first, this time in a trial of metastatic breast cancer patients with HER2-low and HER2-ultralow tumors. Researchers also presented the first data supporting Enhertu as a first-line treatment in HER2-positive metastatic breast cancer.  Further, interim results from the DESTINY-Breast07…

Researchers at the Baylor College of Medicine have identified a protein called PKMYT1 as a promising marker for a form of drug-resistant breast cancer, as well as a potential drug target for patients that currently face a very poor prognosis. Up to 80 percent of deaths from breast cancer are…

Scientists from King’s College London have made a significant breakthrough in the treatment of aggressive breast cancer by developing a tailored drug that exploits the cancer cells’ weaknesses. This innovative approach, published in Clinical Cancer Research and funded by Breast Cancer Now, offers new hope for patients with triple-negative breast…

Researchers at the Hunan Normal University in China have discovered that the expression levels of a protein called retinitis pigmentosa GTPase regulator interacting protein 1-like (RPGRIP1L) may serve as a new prognostic marker for invasive breast cancer (BRCA). Published in The FASEB Journal, the study suggests that RPGRIP1L could provide…

Researchers from the Vanderbilt-Ingram Cancer Center identified new genome-wide gene variants at 12 different locations associated with breast cancer in women of African ancestry. They discovered that variants in three of the 12 were associated with triple-negative breast cancer (TNBC). Historically, women of African ancestry have been largely underrepresented in…