Researchers at City of Hope have discovered new biomarkers that could predict kidney failure in patients with type 1 diabetes (T1D), according to a study published today in Science Translational Medicine. The study, led by Rama Natarajan, PhD, deputy director of the Arthur Riggs Diabetes & Metabolism Research Institute at…

Researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) have discovered that a metabolite found in urine predicts kidney failure from type 2 diabetes five to 10 years early. This new research, published in the Journal of Clinical Investigation, showed that adenine, a…

A rare genetic mutation could help explain why some families are more susceptible to diabetes and kidney failure, according to a new study led by University of Utah Health scientists. The discovery — a defect in ADIPOQ, which encodes the adiponectin protein — was made within multiple generations of a…

Researchers at the Fujita Health University in Japan report that adding a measure of how well kidneys are filtering blood called estimated glomerular filtration rate (eGFR) to an existing risk measure can more accurately predict sudden cardiac death (SCD) in patients with congestive heart failure. This new measure of risk,…

Researchers from the Brigham and Women’s Hospital, reporting today in the journal JAMA Cardiology, have found links between patients admitted to the hospital for heart failure and a higher risk of kidney disease. The broad-based study, conducted across 372 participating sites, included adults 65 years and older hospitalized for heart…

Chinese scientists have achieved organ function of longer than six months in a macaque with a transplanted, gene edited, pig kidney, according to news reports, by Xinhua News, South China Morning Post, and the Global Times. This comes shortly after Harvard Medical School researchers transplanted a genetically modified pig kidney…

The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular disease shows these drugs have significant benefits in people with and without diabetes. In both types of patients, the combined reduction in the risk of kidney failure, worsening kidney function, and death due to…

An artificial intelligence (AI)-based tool developed at the University of Coventry in the U.K. can help enhance decision making about kidney transplants by providing information about likely outcomes. Making the decision about who will receive an organ from a deceased donor is always a difficult one, as many people need…

What could be the first precision medicine for APOL1-mediated kidney disease (AKMD) has successfully completed a Phase I trial. People of African ancestry are at greater risk of this disease. The drug, AstraZeneca’s AZD2373, is an antisense oligonucleotide that targets APOL1 mRNA to reduce its protein synthesis and is in…

Semaglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist designed to treat type 2 diabetes, is also effective at improving cardiovascular and kidney health and reducing the risk for death in people with type 2 diabetes and kidney disease. As reported in the New England Journal of Medicine, the patients randomized…

A clinical trial sponsored by the National Institutes of Health (NIH) has shown that acetaminophen reduces the risk of sepsis patients experiencing organ damage or developing acute respiratory distress syndrome. The study results, published in JAMA, showed that while patients in the trial did not show improved mortality rates regardless…

A combined industry and academia research project aiming to collect biomarkers and find therapeutic solutions for diabetic kidney disease will launch in Montreal with support from Roche, the Quebec Consortium for the Discovery of Medicines (CQDM), the Jewish General Hospital Foundation, local government, and other sources. Brent Richards, a professor…

New research published in Cell Reports Medicine from a recent clinical trial shows that adhering to a ketogenic diet can effectively control polycystic kidney disease (PKD). The clinical study is the first randomized trial of its kind that examining the ketogenic metabolic therapy as a treatment strategy for PKD. The…

Heart health experts are declaring the overlapping effects of obesity, Type 2 diabetes, chronic kidney disease, and cardiovascular disease as a new syndrome—cardiovascular-kidney-metabolic syndrome, or CKM. This change, they say, is prompting rethinking of how they predict long-term cardiovascular risks. A presidential advisory from the American Heart Association (AHA), published Monday in the…

New data from researchers at VCU Massey Cancer Center shows that kidney cancer drugs that block blood vessel growth as a part of treatment significantly elevate the risk of heart problems in younger patients. The study, published today in the Journal of the National Comprehensive Cancer Network, assessed the incidence…