Researchers led by the Icahn School of Medicine at Mount Sinai have developed an artificial intelligence (AI)-based program that can accurately pick up neurological problems in newborns admitted to the neonatal intensive care unit (NICU) from video. If these findings, published in eClinicalMedicine, are validated and scaled up, then it…

Previous research has demonstrated that the lack of the gene MECP2 on microglial cells alters its functions, which might be implicated in Rett syndrome pathogenesis. Now, researchers at the University of California, San Diego (UCSD), have discovered an experimental cancer drug that targets faulty microglia which may improve cognitive function…

Mapping dysfunctional circuits in the brain by electrically stimulating areas deep within it could improve the treatment of four neurological disorders, research suggests. The findings, in Nature Neuroscience, may help identify new targets and strategies for dystonia, Parkinson’s disease, Tourette Syndrome, and obsessive-compulsive disorder (OCD). The researchers identified those circuits…

A review article published this week in the Journal of Internal Medicine points to early evidence that gamma rhythm stimulation could be a treatment for neurological disorders including Alzheimer’s disease (AD). The review of studies was conducted by the same lab at MIT that published a groundbreaking study in 2016 that…

Clinical-stage biotechnology company Rapport Therapeutics, which has a focus of developing targeted small molecule drugs for the treatment of neurological disorders, launched today with a $100 million Series A financing led by Third Rock Ventures, ARCH Venture Partners and Johnson & Johnson Innovation. The company’s lead candidate is currently in…

Digital diagnostics company DiagnaMed Holdings announced today that it has acquired the exclusive worldwide licensing agreement with the tech transfer corporation of the University of Kansas for the development and commercialization of a novel virtual reality (VR) and artificial intelligence (AI) neurodiagnostic system for the evaluation, diagnosis and monitoring of…

Researchers at University College London (UCL) have developed a new gene therapy approach for epilepsy and potentially other neurological and psychiatric diseases that works by reducing the excitability of overactive brain cells. The new closed-loop gene therapy approach enables the on-demand expression of a gene that tamps down the activity…

Research from the University of North Carolina at Chapel Hill School of Medicine shows that gene mutations can impact how effective psychedelic drugs are for treating conditions such as anxiety and depression. Recent clinical trials have shown that psychedelic drugs such as psilocin and LSD have beneficial effects for people…

Researchers based at the University of California San Diego (UCSD) have developed an app that can scan people’s pupils to search for early signs of neurological conditions such as Alzheimer’s disease, as well as other cognitive disorders. The app makes use of the near-infra red camera, which is installed in…

Clinical-stage biopharma company Cyclerion Therapeutics and artificial intelligence (AI) drug developer Ariana Pharma announced on Wednesday a collaboration to identify biomarkers of therapeutic response aimed at boosting Cyclerion’s investigational therapeutics program in neurological and neuropsychiatric diseases associated with cognitive impairment leveraging Ariana’s AI technology. “Ariana integrates disease biology, mechanism information,…

Different brain diseases feature different blood levels of certain biomarkers, according to a new study in Journal of Neurology, Neurosurgery, and Psychiatry. This could be a major step forward for diagnosis, treatment, and trials, which all current depend on clinical diagnosis, positron emission tomography, and cerebrospinal fluid analysis. The lead…

Researchers at the Max Planck Institutes of Neurobiology and of Biochemistry report in the EMBO Journal that they have developed a mouse line that makes the state of protein balance visible in the mammalian brain for the first time. Using this model, researchers can now study in more detail, the processes…

A gene therapy developed at University College London and Great Ormond Street Hospital to treat the rare neurodegenerative condition Dopamine Transporter Deficiency Syndrome (DTDS) achieved promising results in a lab and mouse model. Based on the results, the researchers have been given the go-ahead to proceed to a clinical trial…

Millimeter-wide 3-D models that mimic vital aspects of the human nervous system have been developed in a step that could accelerate drug research for neurological conditions such as multiple sclerosis (MS). The models will be used to study myelin. Researchers say the models are the most natural representation of human…

Researchers at the Baylor College of Medicine report that they have found that microbes in the gut may contribute to certain symptoms associated with complex neurological disorders. Their study “Dissecting the contribution of host genetics and the microbiome in complex behaviors,” published in Cell, also suggests that microbe-inspired therapies may one…