A study led by researchers in Madrid has uncovered the likely cause of the severe symptoms of atherosclerosis seen in children with the genetic aging disorder Hutchinson-Gilford progeria syndrome. As reported in The Journal of Clinical Investigation, the research team found that increased activity of two transcriptional activator proteins YAP…

A team of researchers from the Vanderbilt University Medical Center, the Columbia University Irving Medical Center, and the Technical University Munich has found that smooth muscle cells lining the arteries of atherosclerosis patients can develop into other cell types with traits similar to cancer. These findings could pave the way…

A molecule known as resolvin T4 (RvT4) could help treat patients with rheumatoid arthritis-associated atherosclerosis in the future, according to research led by Queen Mary University of London. Between one and two million people in the U.S. have the degenerative autoimmune joint condition rheumatoid arthritis. Like many autoimmune conditions, people…

A new study published in Circulation Research demonstrates the increased risk of Alzheimer’s disease (AD) posed by the APOE4 variant is also associated with the risk of subclinical atherosclerosis in middle age. Further, the APOE2 variant protects against the development of subclinical atherosclerosis, similar to its protection against the development…

New research conducted at Madrid’s Centro Nacional de Investigaciones Cardiovasculares (CNIC) suggests that young people are more susceptible to the effects of risk factors for developing atherosclerosis—the hardening and narrowing of arteries due to the accumulation of plaque. The study, co-led by Valentín Fuster, MD, PhD and Borja Ibáñez, MD,…

There is new evidence that mutations in p53 contribute to the development of atherosclerotic cardiovascular disease. These findings “broaden our knowledge of how the acquisition of mutations in blood cells, a phenomenon called clonal hematopoiesis, acts as a cardiovascular risk factor,” said Valentín Fuster, President of Mount Sinai Heart and…

Newly identified markers of atherosclerotic coronary artery disease (ASCAD) were pinpointed in a study using digital twins. The work was carried out by multi-omics specialist G3 Therapeutics and AI company Aitia, which has Gemini Digital Twin technology. These new findings suggest triglyceride-rich LDL particles could be a novel diagnostic marker…

Researchers at the Salk Institute and UC San Diego (UCSD) report in new finding published today in the journal Immunity, that they have uncovered a link between mitochondria, inflammation, and two genes that normally help regulate blood cell growth—DNMT3A and TET2— that, when mutated, are associated with an increased risk…

Targeting PERK in smooth muscle cells can block and decrease buildup of atherosclerotic plaque in mouse models, according to a new study from researchers at UTHealth Houston. Smooth muscle cells have not been a major study focus for this disease until recently. The research was published this week in Arteriosclerosis, Thrombosis,…

Atherosclerosis, the accumulation of plaque inside artery walls, can lead to heart attacks and strokes. There are many factors that can contribute to the weakening of the arteries and increasing deposits of fat and cholesterol, including conditions such as high cholesterol, diabetes, high blood pressure, and obesity. However, a new…

Genetic traits influence the composition of atherosclerotic plaque and affect patient risk of stroke or heart attack, according to a new study from researchers at the Karolinska Institutet and a global team of collaborators. Using genetic data, the researchers were able to categorize patients into three different risk groups.  The…

Extended estrogen suppression in postmenopausal breast cancer does not increase patients’ risk of coronary artery calcification, as some prior studies had indicated, new evidence from an international collaboration shows. This finding helps address a key issue in treating this population  Aromatase inhibitors are a mainstay in treating hormone receptor-positive postmenopausal…

New research funded by the NIH National Heart, Lung, Blood Institute (NHLBI) has identified a combination of biomarkers that can predict a woman’s risk of developing cardiovascular disease over the next 30 years. The study, presented as late-breaking research at the European Society of Cardiology Congress 2024 and published in…

It is well known that so-called “hyperactive” blood platelets can result in abnormal blood clotting and an increased risk of heart attack, stroke, and peripheral artery disease. But measuring the clumping tendency—called aggregometry—to develop accurate patient risk assessments is not currently possible due to broad variations in lab testing methods.…

Early Alzheimer’s disease (AD) biomarkers’ start showing up during midlife, whereas late-life measures of AD, such as neuronal injury and astrogliosis biomarkers, are all associated with manifest dementia, according to new research from a team that looked at blood samples from over 1,500 people in both mid- and later-life. Neurofilament…