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Published on September 6, 2023
New evidence suggests lymph nodes play a key role in why tumors that have spread to the brain respond to immunotherapy, while glioblastoma, which originates in the brain, does not. “Typically, antigen presenting cells (e.g., conventional dendritic cells, cDCs) are recruited to the tumor, where they phagocytose dead or dying tumor…
Published on July 7, 2023
A new tool developed by researchers at Harvard Medical School (HMS) uses artificial intelligence (AI) to determine the molecular profile of a patient’s brain tumor during surgery. The advance can help surgeons know how much tissue to remove during surgery or whether to place tumor-killing drugs directly in the brain…
Published on March 24, 2023
A multicenter research and development effort led by a team of neurosurgeons and engineers at Michigan Medicine at the University of Michigan (U-M) have developed a screening system call DeepGlioma that employs rapid imaging plus artificial intelligence (AI) to detect brain cancer mutations in under 90 seconds. “This AI-based tool…
Published on May 18, 2022
A novel technology designed to precisely image aggressive brain cancers and guide treatment is being prepared for a phase 1 trial in glioblastoma, the most common type of brain cancer. The new MRI nanotechnology targets a specific marker, fibroblast activation protein (FAP), that is found in the majority of solid…
Published on February 16, 2022
When Anne Donguy’s son, Anatole, was diagnosed with diffuse midline glioma in May 2018, she joined the ranks of many parents around the world looking for any effective treatment for their child. Living in Stockholm, Sweden, Anne and her family eventually learned that the most hopeful drug treatment, Onc201, was…
Published on March 8, 2021
Brain metastases are the most common tumor of the brain with a very poor prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors like anti-PD1, anti-PD-L1, and anti-CTLA4 drugs. One of the limitations of these drugs over the long-term in brain tumors is that…
Published on February 16, 2021
Scientists at Dana-Farber Cancer Institute, Massachusetts General Hospital, and the Broad Institute of MIT and Harvard, reported the discovery of a potential new target for immunotherapy of malignant brain tumors. The team used single-cell RNA sequencing (RNA-seq) to study gene expression and the clonal landscape of tumor-infiltrating T cells across…
Published on January 9, 2020
If you dispatch a suicide gene, you want to make sure that it bypasses healthy cells on its way to harmful cells, such as cancer cells. What’s more, you want to make sure that the suicide gene is sent via a delivery system that treads lightly—especially if the suicide gene…
Published on November 7, 2018
Detecting, as well as treating, brain cancers has historically presented a challenge for researchers and clinicians. Though, with new techniques such as liquid biopsy and advanced sequencing methods, identifying tumors within the brain could become considerably easier. Now, investigators at the Cancer Research UK (CRUK) Cambridge Institute have made considerable…
Published on August 20, 2018
A cache of brain cancer biomedical data, REMBRANDT (REpository for Molecular BRAin Neoplasia DaTa) hosted and supported by Georgetown, has been made available free to researchers worldwide. It is one of only two such large collections in the United States. Unlike many other such datasets, REMBRANDT contains not just genomic…
Published on February 3, 2017
Philadelphia Coalition for a Cure (PC4C) said today it will partner with Children's Hospital of Orange County (CHOC) on a study of brain tumors in adults and children that will use NantHealth’s GPS Cancer molecular profiling and diagnostics test. GPS Cancer integrates whole genome (DNA) sequencing of over 20,000 genes…
Published on December 7, 2016
Scientists at the Translational Genomics Research Institute (TGen) have just published evidence suggesting that survival from glioblastoma (GBM), an aggressive and deadly form of brain cancer, could be determined by the complexity of their tumor. The findings from this new study, which were published recently in Neuro-Oncology through an article…
Published on December 20, 2023
Researchers observed that cells that are present in cancerous brain cells but not in normal brain tissue—known as cancer-associated fibroblasts (CAFs)—secrete a protein that stimulates breast cancer cells in the brain to migrate and invade more widely. The excreted protein, fucosylated poliovirus receptor (PVF), was shown in mouse models to…
Published on December 5, 2023
Research hospital Seattle Children’s announced today the spinout of its for-profit company BrainChild Bio, Inc., which will develop CAR T-cell therapies targeting pediatric central nervous system (CNS) cancers. Underpinning the new company will be a license to the CAR T-cell technology that has been developed at Seattle Children’s and will…
Published on July 13, 2023
The genetic drivers of papillary craniopharyngiomas, a rare brain tumor, were targeted by a combination treatment that led to a 91 percent response rate in a new trial. The trial was led by investigators from the Mass General Cancer Center and the first multicenter treatment protocol for this type of…