Antiviral, mutagenic enzymes that edit the genomes of cancer cells drive the development of early bladder cancer, researchers have discovered, with chemotherapy further contributing further mutations that hamper treatment success. The team also revealed how chemotherapy resistance was further assisted by overactive genes located within abnormal, circular segments of DNA…

A new study, published in Neurology, explores whether multiple sclerosis (MS) may be linked to a higher risk of certain cancers. Conducted by researchers at Rennes University in France, the study found a slight increase in the incidence of cancers like bladder, brain, and cervical cancer among people with MS…

The paradoxical surge of colorectal cancer (CRC) cases among younger adults is one of the biggest questions for oncology today. Now there is new evidence that an unexpected driver behind the mysterious rise of colon cancer cases in young adults is high blood-sugar levels.  This study found that young adults…

A blood test that measures the number of circulating tumor cells (CTCs) at the time of metastatic prostate cancer diagnosis can predict treatment response, disease progression, and overall survival, regardless of subsequent therapies over time, shows a study led by University of Southern California (USC) researchers. The test could be…

A recent study by researchers at the Baylor College of Medicine has shed light on the role of DAPK3 in triple-negative breast cancer (TNBC), detailing its regulation of epithelial-mesenchymal transition (EMT) which is a process linked to cancer metastasis. This research, published in the journal PNAS Nexus, provides a better…

A new consortium called Thera4Care has launched to provide better access to precision medicine for treatment of cancer in Europe. More specifically it aims to broaden access to theranostics (also known as theragnostics), a combination of therapeutic treatment and diagnostic, which can be very beneficial for cancer patients. An example…

A recent study from investigators at the UCLA Health Jonsson Comprehensive Cancer Center has found that common treatments for breast cancer—chemotherapy, radiation, and surgery—may contribute to accelerated biological aging in survivors. The research, published in the Journal of the National Cancer Institute, demonstrates that markers of cellular aging such as…

Commercially available artificial intelligence (AI) algorithms that help radiologists immediately detect breast cancer at mammography screening can also highlight women who are at risk years before their eventual diagnosis, research indicates. The findings, reported in JAMA Network Open, could offer a pathway for personalized screening that may lead to the…

The question of whose DNA or RNA was used to develop a complex genetic test, such as those that use AI to identify patterns of genetic variants or gene expression levels, is fundamental to its applicability—the people most like those who were used to develop the test are the most…

One of the most alarming recent health trends is the rise in “early-onset cancers”—those diagnosed in adults between the ages of 18 and 49. Advancing age is the top risk factor for cancer in general. Many individuals in this age group are too young for recommended routine cancer screenings—for example,…

A study led by researchers at the Duke Cancer Institute has uncovered new insights into the role of estrogens in cancer growth, particularly in breast cancers that lack estrogen receptors. The research, published in Science Advances, describes how estrogens not only decrease the ability of the immune system to attack…

Australian researchers have shown that circulating antibodies against tumor antigens can be used as an accurate biomarker for the early detection of melanoma. The findings were presented by Cristina Vico-Alonso, MD, lead researcher from the Victorian Melanoma Service, in Melbourne, Australia, at the European Academy of Dermatology and Venereology Congress…

In a new study in mice, researchers from the University of California, Irvine (UCI), demonstrated how disruption of the circadian rhythm may accelerate the progression of colorectal cancer (CRC) by affecting the gut microbiome and intestinal barrier function. The new study offers new avenues for prevention and treatment strategies. The…

Owkin and AstraZeneca have partnered on an AI-powered tool to pre-screen for germline BRCA (gBRCA) in breast cancer, directly from digitized pathology slides. This tool aims to significantly accelerate and expand access to gBRCA testing that many patients may not be considered for. The solution is currently in development and…

The international ovarian tumor analysis (IOTA) ADNEX ultrasound test detected 96% of ovarian cancers in postmenopausal women and should become standard of care in the U.K., according to researchers who just published a new study comparing methods. “This is the first time that a head-to-head study of all available ovarian…