A new study from researchers at the Icahn School of Medicine at Mount Sinai has uncovered critical insights into why aging is the most significant risk factor for cancer. The research, published in Science, details how the aging immune system contributes to tumor growth and offers potential new avenues for…

Researchers at Mass General Cancer Center report that statins, commonly used to lower cholesterol, may inhibit chronic inflammation pathways that can contribute to the development of cancer. “Chronic inflammation is a major cause of cancer worldwide,” said senior author Shawn Demehri, MD, PhD, a principal investigator at the Center for…

Scientists at the German Cancer Research Center (DKFZ) sought to determine the role of gastrointestinal B cells in the development of nonalcoholic steatohepatitis (NASH), fibrosis, and NASH-induced HCC. They discovered B cells promote liver cancer with a dual strategy. Their findings are published in the Journal of Hepatology. “Worldwide, fatty…

Pancreatic cancer remains the most lethal subtype of the disease due to the difficulty diagnosing it in its earliest stages. In all only about one-in-seven people diagnosed with the disease are still living five years later, as early detection and treatment are the keys to cancer survival. Now, a team…

A new study shows, for the first time, that telomeres set the damage threshold a cancer cell can sustain and above which cells cannot continue to divide and die. These results open new possibilities for cancer therapeutics. Telomeres are the ends of chromosomes that keep shortening at each cell division,…

Researchers at the Institute for Cancer Research (ICR), London, have published findings indicating that non-coding “junk” DNA, far from being harmless and inert, could potentially contribute to the development of cancer. Their study, which appears in Nature Communications, has shown how non-coding DNA can get in the way of the replication…

A team of researchers at the University of California, San Francisco was selected to receive a five-year, $25 million Cancer Grand Challenges award to investigate the very early stages of cancer development. The team, called PROMINENT (PROMotion to INform prevENTion), aims to discover what triggers normal cells to become cancerous…

A fundamental organizing principle in cellular biochemistry is the formation of droplets through a process of liquid-liquid phase separation. A new study from researchers at the University of Virginia (UVA) School of Medicine offers evidence that these liquid condensates regulate the structure of chromatin and the expression of genes in…

High levels of the inflammatory immune biomarker interleukin (IL)-33 can trigger abnormal cell growth and division in skin and pancreatic cells, shows research from Massachusetts General Hospital. Chronic inflammation is known to be linked to a number of different cancers including skin, colon and pancreatic cancer. IL-33 is mostly known…

Researchers from the Johns Hopkins Kimmel Cancer Center and Bloomberg Kimmel Institute for Cancer Immunotherapy using a mouse model found that a microbe commonly associated with colitis and colon cancer may play a role in the development of some breast cancers. “Existence of distinct breast microbiota has been recently established…

Understanding the processes involved in cancer development are a huge step forward in terms of developing treatment options.  For many types of cancer, that is a painstaking process and after years of research, only a few pathways are discovered. A new study from Pacific Northwest National Laboratory (PNNL) has jumpstarted…

New research published in The Cell from researchers at UC San Diego School of Medicine and Case Western Reserve School of Medicine shows non-coding DNA—often referred to as ‘junk’ DNA because it does not encode for any known function—can contribute to cancer development. The mechanism identified suggests that when an…

Salk Institute researchers have used of a state-of-the-art technology known as single-nucleus (sn) assay for transposase-accessible chromatin (ATAC) sequencing (snATAC-seq) to profile how specific types of mammary cells differentiate during development. The findings, published in Cell Reports, provide new insights into normal breast development, and could ultimately point to new…

Genetically speaking, all humans are 99.9% identical, but that tiny 0.1% variation has signfiicant consequences, influencing everything from the color of your hair or the size of your hads, to your risk of developing a disease. Although variants are scattered throughout the genome, scientists have largely ignored the stretches of…

Researchers at Case Western Reserve University say that a class of diabetes drugs used to treat type 2 diabetes may reduce the risk of the development of colorectal cancer (CRC). The drugs, called glucagon-like peptide-1 receptor agonists, or GLP-1 RAs are medications that are given by injection to lower blood…