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CAR T Cells Can Be Toggled On and Off, Say Dana-Farber Research Team
The researchers engineered OFF-switch CAR T cells that could be quickly and reversibly turned off by administering the drug lenalidomide, after which the CAR T cells would again recover their anti-tumor activity.
CAR-T Cells Engineered to Produce Small-Molecule Cancer Drugs
Scientists have developed a new type of CAR-T cells that act as a “micropharmacy." The new versions may help overcome some limitations of existing CAR T cells.
Transcription Factor Extends Reach of Tumor-Fighting CAR-T Cells
Researchers have demonstrated how cancer-fighting T cells can be engineered to clear tumors without succumbing to T cell exhaustion, a phenomenon that results in T cells giving up the antitumor fight after prolonged periods of overactivity.
Engineered CAR-Natural Killer Cell Immunotherapy Targets Cancer Cells, While Sparing Healthy Cells
In vitro experiments showed that the CAR-NK cells effectively killed different breast cancer cell lines and an HER2-over-expressing ovarian cancer line. And, unlike CAR-T cells, the HER2 CAR-NK cells could discriminate between HER2-expressing cancer cells and healthy HER2-expressing cells.
Loss of Endometrial Stem Cells Prior To Conception Raises Miscarriage Risk
Highly proliferative mesenchymal stem cells are recruited into the lining of the womb at the time of embryo implantation. These cells appear critical in pregnancy to accommodate the rapidly growing placenta and fetus and are depleted in women with recurrent pregnancy loss, according to new U.K. research.
Cellectis Reports Proof-of-Concept for “Smart” CAR T-Cells
The T-cells are capable of sensing and reacting to tumors with micro secretions of therapeutic proteins that improve their ability to fight cancerous cells, potentially paving the way for tightly-controlled, highly active—and potentially safer—CAR T-cell treatments.
CAR-Engineered Stem Cells Show Promise in Treating HIV
The engineered cells could also treat other infections that can re-emerge after many years of suppression or dormancy, researchers say
New Nanoparticles Carrying mRNA Can Perform In-Lung Gene Editing
A newly created nanoparticle that carries a messenger RNA (mRNA) payload that can be administered to the lungs may offer a method to provide an inhalable treatment for cystic fibrosis and other lung diseases.
Antibiotics Blunt CAR T Effect in Lymphoma Treatment
Gut microorganisms influence non-Hodgkin lymphoma patient outcomes to chimeric antigen receptor T-cell therapy (CAR T) a recent multinational research collaboration finds.
Study Significantly Improves CAR T Cell Therapy for Solid Tumors
University of Pennsylvania researchers develop an improved CAR T cell therapy approach for solid tumors by overcoming T cell exhaustion.