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T cells and cancer cells

CAR T Cells Can Be Toggled On and Off, Say Dana-Farber Research Team

The researchers engineered OFF-switch CAR T cells that could be quickly and reversibly turned off by administering the drug lenalidomide, after which the CAR T cells would again recover their anti-tumor activity.
cancer cells

CAR-T Cells Engineered to Produce Small-Molecule Cancer Drugs

Scientists have developed a new type of CAR-T cells that act as a “micropharmacy." The new versions may help overcome some limitations of existing CAR T cells.
CART Cell Cancer Immunotherapy

Transcription Factor Extends Reach of Tumor-Fighting CAR-T Cells

Researchers have demonstrated how cancer-fighting T cells can be engineered to clear tumors without succumbing to T cell exhaustion, a phenomenon that results in T cells giving up the antitumor fight after prolonged periods of overactivity.
Lymphocytes attacking a cancer cell, illustration

Engineered CAR-Natural Killer Cell Immunotherapy Targets Cancer Cells, While Sparing Healthy Cells

In vitro experiments showed that the CAR-NK cells effectively killed different breast cancer cell lines and an HER2-over-expressing ovarian cancer line. And, unlike CAR-T cells, the HER2 CAR-NK cells could discriminate between HER2-expressing cancer cells and healthy HER2-expressing cells.
Pregnancy Bump

Loss of Endometrial Stem Cells Prior To Conception Raises Miscarriage Risk

Highly proliferative mesenchymal stem cells are recruited into the lining of the womb at the time of embryo implantation. These cells appear critical in pregnancy to accommodate the rapidly growing placenta and fetus and are depleted in women with recurrent pregnancy loss, according to new U.K. research.
T-cells attacking cancer cell  illustration of  microscopic photos

Cellectis Reports Proof-of-Concept for “Smart” CAR T-Cells

The T-cells are capable of sensing and reacting to tumors with micro secretions of therapeutic proteins that improve their ability to fight cancerous cells, potentially paving the way for tightly-controlled, highly active—and potentially safer—CAR T-cell treatments.
U.S. researchers have created chimeric antigen receptor (CAR)-engineered hematopoietic stem/progenitor cells (HSPCs) that have shown potential to treat HIV (pictured) and other infections that can re-emerge after many years of suppression or dormancy. [Source: Donald Bliss

CAR-Engineered Stem Cells Show Promise in Treating HIV

The engineered cells could also treat other infections that can re-emerge after many years of suppression or dormancy, researchers say
Human Respiratory System Lungs Anatomy

New Nanoparticles Carrying mRNA Can Perform In-Lung Gene Editing

A newly created nanoparticle that carries a messenger RNA (mRNA) payload that can be administered to the lungs may offer a method to provide an inhalable treatment for cystic fibrosis and other lung diseases.
CAR T-Cell Immunotherapy

Antibiotics Blunt CAR T Effect in Lymphoma Treatment

Gut microorganisms influence non-Hodgkin lymphoma patient outcomes to chimeric antigen receptor T-cell therapy (CAR T) a recent multinational research collaboration finds.
CAR T-Cell Immunotherapy

Study Significantly Improves CAR T Cell Therapy for Solid Tumors

University of Pennsylvania researchers develop an improved CAR T cell therapy approach for solid tumors by overcoming T cell exhaustion.


Inside Precision Medicine