A new review published in The Lancet Neurology by researchers at Mass General Brigham presents findings indicating that cardiovascular disease risk may be increased by traumatic brain injury (TBI). The review presented evidence of the long-term associations between TBI and cardiovascular disease noting that post-injury comorbidities, as well as neuroinflammation,…

Research at Kaiser Permanente Southern California shows that some types of HIV pre-exposure prophylaxis (PrEP) therapy may have a better cardiovascular risk profile than others. As reported in JAMA Network Open, use of tenofovir alafenamide fumarate (TAF) for HIV PrEP was linked to increased risk for high blood pressure and…

Topline results from the large-scale Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT) clinical study released today show that the Novo Nordisk obesity drug reduces the risk of major adverse cardiovascular events by 20 percent. The SELECT trial is the first to demonstrate the…

The association between obstructive sleep apnea and the risk of developing cardiovascular condition is well established. Now, new research published in the American Journal of Respiratory and Critical Care Medicine, by Harvard Medical School and Brigham and Women’s Hospital investigators has shown that increased cardiovascular risks from obstructive sleep apnea…

An analysis of more than 460 million lipid test results from 17 countries on five continents has provided evidence that variation in cardiovascular disease risk is based on influences from where a person lives and their sex. The study, performed by researchers at Johns Hopkins University and the Quest Diagnostics-led…

Almost half of patients with head and neck squamous cell carcinoma (HNSCC) have at least one suboptimally controlled cardiovascular (CV) risk factor, which in turn may be associated with an increased risk for CV events and death, suggests a study among US veterans. The findings show that “CV risk mitigation…

Research shows polygenic risk scores (PRS) modestly but significantly improve risk predictions for atherosclerotic cardiovascular disease in the diverse Million Veteran Program cohort. Writing in JAMA Cardiology, Jason Vassy, an associate professor at Harvard Medical School and a clinician at Veterans Affairs Boston Healthcare System, and colleagues report that having…

A study by UK Biobank has found that cancer survivors may be at long-term heightened risk of cardiovascular disease, irrespective of traditional underlying risk factors, with those who have survived blood cancer and breast cancer, most vulnerable. While most of the evidence to date suggests that the highest risk of…

A study led by Yale University School of Medicine shows a significant link between prenatal depression and subsequent cardiovascular disease. The study was reported in the Journal of the American Heart Association and showed women who were depressed during pregnancy had a 32–83% increased risk of developing some form of…

Sequencing leader Illumina announced it has entered a partnership with Henry Ford Health in Detroit to assess the impact and utility of comprehensive genomic profiling (CGP) for patients with cardiovascular disease. The program, dubbed CardioSeq, will comprise the implementation of clinical studies using next-generation sequencing technology, including whole-genome sequencing, to…

The Genotype and Phenotype Database of Monogenic Cardiovascular Disease, or CardioGen, has been established by China’s BGI Genomics, together with the National Center for Cardiovascular Diseases, Fuwai Hospital, and the State Key Laboratory of Cardiovascular Diseases. CardioGen collects and integrates information about gene-causing diseases and clinical phenotype information of patients found in…

Patients treated for sepsis during hospital stays were at much greater risk of cardiovascular events and rehospitalization for any cause, or death, for as long as 12 years after, according to a study published today in the Journal of the American Heart Association. The study looked at claims data for approximately 2.3…

Researchers in Canada have helped explain how the PCSK9 protein degrades low-density lipoprotein (LDL) receptors. Their findings add key insight to the understanding of how atherosclerosis develops. The richest cholesterol particles in the bloodstream, LDLs are strongly linked to cardiovascular disease. But PCSK9 also plays a role in cancer. The…

A study of more than 10,000 patients treated in the Mass General Brigham network shows that a remote cholesterol and blood pressure management program was successful at significantly lowering blood pressure (BP) and low-density lipoprotein (LDL) cholesterol in participants. The researchers believe the success of this program shows it could…

Researchers at Brigham and Womens Hospital in Boston, MA have succeeded in markedly reducing the levels of bad cholesterol in patients suffering from cardiovascular disease in a clinical trial using the investigational drug Olpasiran. Cardiovascular disease is the leading cause of death for people of most racial and ethnic groups in the United…