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Published on November 29, 2022
The University of Alabama at Birmingham (UAB) Cardiogenomics Clinic announced it will partner with genomic software company Allelica, which specializes in implementation of polygenic risk scores (PRS), for a clinical implementation study on the use of PRS to inform clinical uses of PRS for the prevention of coronary artery disease…
Published on July 8, 2022
A new health economics study published last month online ahead of print publication in the Journal of the American Heart Association shows that adding a polygenic risk score (PRS) as an additional risk-enhancing factor in the current standard-of-care atherosclerotic cardiovascular disease Pooled Cohort Equation (PCE) risk assessment would provide cost…
Published on March 16, 2022
A new smartphone app can calculate users’ genetic risk for coronary artery disease (CAD), according to a study by a Scripps Research team. Plus, users at high risk sought out appropriate medication after using the app. In the study, which appears in npj Digital Medicine this month, the researchers detailed how MyGeneRank…
Published on February 26, 2021
An international research team reports that more than one-third of genetic variants that increase the risk of coronary artery disease (CAD) regulate the expression of genes in the liver. These variants also have an impact on the expression of genes regulating cholesterol metabolism. The findings provide valuable new insight into…
Published on October 7, 2020
Researchers based at the RIKEN Center for Integrative Medical Sciences in Yokohama have created a highly accurate polygenic risk score for predicting coronary artery disease risk by combining genome wide association study (GWAS) data from a large Japanese cohort with two European cohorts with more than 600,000 participants in total.…
Published on March 20, 2024
Ohio State University researchers have published a study that shows treating people with heart disease who have symptoms of depression and anxiety significantly decreased visits to the emergency room and rehospitalizations. The research, published today in the Journal of the American Heart Association, noted that depression and anxiety are common…
Published on March 5, 2024
Research lead by a team from Charité–Universitätsmedizin Berlin, Germany has shown that coronary artery calcium scoring with CT can identify patients identify which patients are at a very low risk of heart attack or stroke. The findings may one day help patients with stable chest pain, but a low risk…
Published on February 12, 2024
Already a popular topic, the launch of the large language model-based chatbot, ChatGPT, at the end of 2022 increased excitement around artificial intelligence (AI) in the media to fever pitch. This event triggered many heated debates about the technology and its numerous potential applications over the past 12 months. There…
Published on February 2, 2024
Even people with moderately elevated low-density lipoprotein cholesterol (LDL-C) have higher risk of heart disease if they also had a variant for familial hypercholesterolemia (FH), according to new research. The long-term study included over 20,000 patients and reinforces the value of genetic testing for this condition. The study was published…
Published on November 28, 2023
Biomedical engineers from Duke University report they have developed a method that combines smartwatch data with a digital twin framework that can predict a patient’s risk of developing heart disease or having a heart attack. The method can digitally mimic an entire week’s worth of an individual’s heartbeat, far eclipsing…
Published on June 20, 2023
While coronary CT angiography (CCTA) has become a highly effective tool to noninvasively screen low or intermediate risk patients for coronary heart disease, its limitations have prevented CCTA from being used on high-risk patients. Now, a new CT technology called ultra-high-resolution coronary CT angiography (UHR-CCTA) has shown promise to also…
Published on January 13, 2023
CRISPR gene editing could protect cardiac tissue from damage caused by a stroke or heart attack, according to research published in the journal Science. Currently, CRISPR-Cas9 gene editing is typically used to correct specific genetic mutations before the onset of disease, with treatment usually offered to a limited group of…
Published on December 21, 2022
An in silico marker for coronary artery disease (CAD) has been found by researchers at the Icahn School of Medicine at Mount Sinai in New York using machine learning and clinical data from electronic health records. The findings, published online this week in The Lancet, aim to provide non-invasive, more targeted diagnosis and…
Published on June 3, 2022
Researchers based at the Rocky Mountain VA Medical Center, Colorado have discovered that a taller stature is associated with an increased risk for several diseases such as atrial fibrillation and peripheral neuropathy. Height was associated with several common conditions such as heart disease and cancer in the past. However, scientists…
Published on April 18, 2022
Researchers from Brigham and Women’s Hospital, Veterans Affairs (VA) Boston Healthcare System, and Harvard Medical School today release polygenic risk scores (PRS) for six common disease as part of the Genomic Medicine at VA (GenoVA) Study. As part of the study, published today in Nature Medicine, the investigators have developed…