A new study conducted by researchers at the Huntsman Cancer Institute at the University of Utah, the Spencer Fox Eccles School of Medicine at the University of Utah, and Boston University Chobanian & Avedisian School of Medicine has found that women with severe endometriosis are 10 times more likely to…

U.K. techbio PrecisionLife has entered into a data access agreement with the University of Oxford to discover personalized treatments for women with endometriosis. The company is licensing the Oxford Endometriosis Gene (OXEGENE) dataset in the hope of identifying genetic differences between women with endometriosis and the underlying mechanisms driving their…

Researchers at the Feinstein Institutes published research findings yesterday in BMC Medicine, that shows the ability to diagnose endometriosis from the molecular and genetic makeup of endometrial tissue shed into the menstrual effluent (ME). The findings bring the possibility of a non-invasive diagnostic for this common debilitating condition that affects…

New research conducted by Baylor College of Medicine, the University of Oxford, the University of Wisconsin-Madison and Bayer AG, offers novel insight into how to treat endometriosis. The researchers performed genetic analyses of humans and rhesus macaques to identify a specific gene, NPSR1, that increases risk of endometriosis. The study…

An especially painful and invasive form of endometriosis could be treated epigenetically, report scientists based at Michigan State University (MSU). To demonstrate this possibility, the scientists pharmacologically inhibited P300, a protein implicated in the dysregulation of endometrial epithelial cells, which normally line the uterus. In severe endometriosis, P300 enjoys relatively…

Women with endometriosis, a painful condition that causes womb-like tissue to grow outside the uterus, have epigenetic changes in the DNA of their reproductive cells that may predispose them to developing the condition. “The findings raise the possibility that differences in methylation patterns could one day be used to diagnose…

DotLab, the San Francisco personalized women’s health company developing a non-invasive diagnostic test for endometriosis, said this week it has completed a $10 million Series A financing. “DotLab plans to use its Series A financing to further clinical validation, expand market access, and continue to grow our team in the…

A new study by researchers at Yale School of Medicine has concluded that progesterone receptor (PR) levels are an important predictor of whether women with endometriosis will respond to first-line treatment for the disease. Progestin-based therapies such as oral contraceptives serve as first-line treatments for managing endometriosis-associated pain. But response…

Women with chronic pelvic pain who also carry a genetic variant in the neuregulin 3 gene (NRG3) are more likely to respond to treatment with gabapentin, shows research led by the University of Edinburgh. Up to 26% of women and those assigned female at birth have chronic pelvic pain. Although…

To dig out the most information from the rapidly expanding multi-omics datasets, they must be integrated. Nonetheless, combining information from genomics, transcriptomics, proteomics, and other omics creates an immense analytical challenge. Taking on that task, however, is well worth the effort. As Nina Gonzaludo, PhD, pharmacogenomics and human leukocyte antigens…

Oriana Papin-ZoghbiCEO and co-founder, AOA Dx Women have been severely underserved when it comes to their health,” says Oriana Papin-Zoghbi, CEO and co-founder of AOA Dx, which is based in Boulder, CO. Bold as that statement sounds, many experts and organizations around the world point out…

For this issue of Inside Precision Medicine focused on gender medicine, I was asked to write a piece about overlooked diseases that affect women. This list is long and includes, among others, endometriosis, polycystic ovary syndrome, fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and several autoimmune disorders like lupus and…

Women’s health is chronically underfunded both in the public and private sectors and has been for many years. No one knows this better than Piraye Yurttas Beim, CEO and founder of Celmatix, a women’s health biotech company focused on improving ovarian health. Since founding Celmatix in 2009, she has been…

Many biologists seek signals of gene expression and study the structure of tissues. Sequencing RNA (RNA-seq) reveals gene expression, and techniques evolved into single-cell RNA-seq (scRNA-seq), which uncovers the gene expression in just one cell. For spatial information about organisms, scientists use microscopy. To put together these two methods, scientists…

Libraries of immune cells displaying diverse repertoires of chimeric antigen receptors (CARs) have been developed that can recognize non-self antigens and display antigen-dependent clonal expansion, with the expanded population of tumor-specific effector cells leading to long-lasting antitumor responses in mouse models of epithelial tumors. Over the past decade, substantial progress…