New research out of Dana-Farber, the Broad, and Harvard Medical School improves our ability to forecast the alloreactivity of hematopoietic cell transplants (HCTs), which could significantly improve patient outcomes in precision immuno-oncology and allogeneic HCT (allo-HCT) and lead to fewer post-transplant diseases. The cause of allo-HCT-related disease The leading cause…

A cross-omics approach identified four distinct molecular profiles of Alzheimer’s Disease, one of these profiles was associated with worse cognitive function and neuropathological features, according to researchers at Beth Israel Deaconess Medical Center (BIDMC) and their collaborators. The symptoms in this poorer prognosis group included significantly higher Clinical Dementia Rating…

A simplified version of multi-omics testing that involves just one blood sample per year can detect the particularly difficult-to-diagnose condition of early pancreatic cancer, a case report has shown. The researchers believe their longitudinal multi-omics monitoring (LMOM) system is more practical than existing approaches, deploying fewer measurements, annual sampling, and…

The National Institutes of Health is establishing a Multi-Omics for Health and Disease Consortium, with approximately $11 million awarded in the consortium’s first year of funding. The program aims to advance the generation and analysis of “multi-omics” data for human health research and seeks to award approximately $50.3 million over…

Seeking to illuminate bottle genomics in the use of genomic data Illumina announces the launch of Illumina Connected Analytics (ICA). This new and integrated bioinformatics package provides a comprehensive, private, cloud-based data platform that allows customers to manage, analyze, and explore large volumes of multi-omic data in a secure, scalable,…

Canopy Biosciences, a provider of gene editing and gene expression products and services, has acquired Zellkraftwerk for an undisclosed price, in a deal designed to expand the buyer into a “multi-omics” company offering genomics expertise with cell and tissue analysis solutions. By expanding its gene editing and genomics analysis portfolio…

Sponsor: Coupling relatively routine datasets such as genomes and transcriptomes with newer types produces an “integrative Personal Omics Profile”. Register for Webinar

Researchers have constructed the first-ever predictive model of inflammatory bowel disease (IBD), revealing the complexity of its immune network through a multi-omics approach—a complexity that they hope will yield potential targets for new treatments. The model consists of individual networks constructed using molecular data generated from intestinal tissue samples isolated…

The trillions of microbes in the human gut play crucial roles in the development and progression of a range of autoimmune diseases, from inflammatory bowel disease to kidney disease and beyond. [CHRISTOPH BURGSTEDT/SCIENCE PHOTO LIBRARY/Getty Images]  As many as one in 10 people in the U.K.…

Research led by the University of Copenhagen sheds light on why people with Down syndrome are at higher risk for the blood cancer leukemia. The study, published in Nature, shows that babies with Down’s have disruptions in gene expression that results in abnormal blood cell differentiation that can lead to…

When it comes to studying and treating cancer, scientists and clinicians often think of applying two key areas of knowledge: the immune system and genomics. The combination of those fields—immunogenomics—is not quite a new field, but it is on the rise. Even in 2015, Robert Holt, PhD, scientific co-director of…

To dig out the most information from the rapidly expanding multi-omics datasets, they must be integrated. Nonetheless, combining information from genomics, transcriptomics, proteomics, and other omics creates an immense analytical challenge. Taking on that task, however, is well worth the effort. As Nina Gonzaludo, PhD, pharmacogenomics and human leukocyte antigens…

A clearer picture of how post traumatic stress disorder (PTSD) and major depressive disorder (MDD) affect the brain has been provided by genomics, possibly pointing to new drug targets and biomarkers for these and related disorders. Researchers from McLean Hospital and colleagues used a multiomic database, single-nucleus RNA sequencing (snRNA-seq),…

Using large proteogenomic datasets, novel renal cell carcinoma (RCC) biomarkers were found in a new study led by University of Michigan Health Rogel Cancer Center researchers. The team carried out integrative analysis of datasets from both non-clear cell and clear cell RCC. Their findings should improve researchers’ ability to diagnose subtypes…

Biologists of all sorts seek the answer to this general question: What happens and where? The complexity of the answer and even the ability to address the question depends intimately on the problem being studied. A chain of technological advances over centuries, however, continues to give biologists tools to explore…