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Data on over-the-counter (OTC) medicine purchases could spot ovarian cancer earlier, according to new research from a team in the U.K.
Researchers from the University of Pittsburgh Swanson School of Engineering were awarded a grant to determine the biology behind cell interactions that cause ovarian cancer to metastasize.
Short-term surveillance can help improve outcomes and treatment costs before preventive surgery in women at high-risk for ovarian cancer.
Known as MAGIC (Malignancy Assessment using Gene Identification in Captured Cells), the algorithm achieved a sensitivity for detecting epithelial ovarian cancer of 95% and an accuracy of 83% for detecting the disease.
Scientists from the University of California (UC), San Diego, and their collaborators have demonstrated how key proteins act together to suppress antitumor activity in high-grade serous ovarian carcinoma (HGSOC) in a mouse model, revealing a new combinatorial strategy to treat this intractable malignancy.
Researchers have uncovered how tumor cells interact with the immune system in ovarian cancer. Utilizing highly multiplex immunofluorescence and image analysis, they investigated how the genetic characteristics of ovarian cancer shape how tumor and immune cells communicate with each other.
The fallopian tube-based organoids may help predict which individuals with BRCA-1 mutations will develop ovarian cancer years or even decades in advance, and could be used to develop personalized therapies.
This study identified mono (ADP-ribose) and NMNAT-2 as potential biomarkers for ovarian cancers, which may allow clinicians to determine which ovarian cancer patients may respond well and which will not and points to the therapeutic potential of developing an inhibitor for PARP-16.
Researchers from the Moffitt Cancer Center have discovered potential reasons why humoral immunity, or antibody-based immunity, appears to be associated with better outcomes in some ovarian cancers, potentially opening a new line of therapeutic intervention.
The research suggests that wide screening of younger women for HBOC should be considered both to prevent more cancers and to help more women at low risk of breast cancer to avoid unnecessary additional screening.