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Published on November 3, 2022
A new 3D bioprinting technology that can create personalized bowel cancer spheroids derived from a patient’s own cells, could provide clinicians with individualized models for testing various therapeutic approaches. The report, from researchers at the University of Bristol in the U.K. and published in Biofabrication, provides a roadmap for clinicians…
Published on October 17, 2022
Researchers from the Perlmutter Cancer Center at NYU Langone Health have detailed a new approach to cancer treatment that seeks to overcome tumors’ evasion of immune surveillance. The investigators show that drugs form stable attachments with the disease-related proteins they target inside cancer cells. The researchers used prior knowledge that…
Published on October 28, 2021
Researchers at the University of Illinois Urbana-Champaign have developed a finely tuned molecular agent, based on the molecule glutathione, that can target lung and other cancer cells for imaging and treatment. The photoacoustic imaging-based companion diagnostic is for the selective detection of elevated glutathione (GSH) in a lung cancer model…
Published on April 17, 2024
With the aim of bringing more real world data to cancer care, Flatiron Health and the National Comprehensive Cancer Network (NCCN) have renewed their collaboration to allow more cancer centers access to Flatiron’s curated data sets, and thus better evaluate and enhance the quality of care given at their sites.…
Published on April 17, 2024
A new class of artificial intelligence (AI) called hypothesis-driven AI, invented recently by Mayo Clinic researchers, offers an innovative way to discover the complex causes of cancer and improve treatment strategies. The team notes that conventional AI is used primarily for classification and recognition, such as facial recognition, or providing…
Published on April 12, 2024
SAN DIEGO—With the exhibition floor about to close on the third day of AACR 2024, most presenters had deserted their posters. But in one of the dozens of rows, several clusters of conversations were happening all around one poster. Several members from Genialis were explaining krasID—an RNA-based biomarker that uses…
Published on April 12, 2024
Reporting in Science Advances, scientists at the Fred Hutchinson Cancer Center in Seattle have presented a blood-based test, known as liquid biopsy, capable of accurately distinguishing between types and subtypes of small cell lung cancer (SCLC), offering hope for precise diagnosis and personalized treatment plans for patients. SCLC, an aggressive…
Published on April 10, 2024
Encouraging results from this trial were presented at the American Association for Cancer Research (AACR) Annual Meeting 2024 by Timothy Yap, MBBS, PhD, of the University of Texas MD Anderson Cancer Center. Specifically, Yap reported that saruparib demonstrated early efficacy and a favorable safety profile in patients with HRR-deficient breast…
Published on April 8, 2024
Enhertu (AstraZeneca and Daiichi Sankyo’s trastuzumab deruxtecan) has become the first tumor-agnostic, FDA-approved, HER2-directed therapy. It is approved for adult patients with unresectable or metastatic HER2-positive (IHC 3+) solid tumors. Enhertu is an antibody drug conjugate (ADC) that consists of a HER2 monoclonal antibody attached to a number of topoisomerase…
Published on April 3, 2024
A team of researchers at Zhejiang University has developed a novel way to use cryo-shocked tumor cells to combat lung cancer. The researchers used a delivery vehicle for CRISPR-Cas9 that is more effective than lipid nanoparticles (LNPs) in treating lung cancer. In a mouse model of non-small cell lung cancer…
Published on April 3, 2024
Aiming to increase access to specialized genetic testing, the Inter-Organization Cancer Genetics Clinical Evidence Coalition (INTERACT) was launched today by Ambry Genetics and collaborators. The group’s mission is to increase access to genetic testing for people with, or at risk of, hereditary cancers. The coalition also seeks impact on medical…
Published on March 27, 2024
A team of researchers at the University of Notre Dame, Massachusetts General Hospital and the National Institutes of Health has now devised a host-directed therapy (HDT) approach to targeting TB, which utilizes the anticancer drug bevacizumab in combination with the hypertension therapy, losartan, to improve blood flow within granulomas and…
Published on March 27, 2024
Researchers from the Antoni van Leeuwenhoek-Netherlands Cancer Institute (AVL) have shown that patients with breast cancer that has spread to the lymph nodes can avoid extensive lymph node removal if the largest node responds fully to primary systemic therapy. In a presentation to the 14th European Breast Cancer Conference, Annemiek…
Published on March 20, 2024
A study led by the Science and Technology Facilities Council (STFC) Central Laser Facility (CLF) has demonstrated for the first time that a crucial interface in a protein that drives EGFR resistance to targeted cancer therapies could act as a target for more effective treatments. This research, published in Nature…
Published on March 20, 2024
Researchers at the University of California, Irvine (UCI), have uncovered the significant roles of two enzymes, APOBEC3A and APOBEC3B, in creating mutations within cancer genomes, opening up new avenues for developing targeted intervention strategies in cancer treatment. Reporting in Nature Communications, the study highlights how these enzymes modify the DNA…