Researchers at the University of California (UC) Irvine have conducted a transcriptomics analysis of Alzheimer’s disease, looking at the spatial differences in gene expression found across the brains of patients with early-stage and late-stage Alzheimer’s, as well as Alzheimer’s disease in Down syndrome. Their results, published in Nature Genetics, uncovered…

Credit: dani3315/Getty Images A better way to characterize neurologic disorders with transcriptomics has been described in a new study. A team examined disease transcriptomes—the set of RNA transcripts from affected brain regions—for 40 different brain diseases—and found they could classify brain diseases into five primary groups based on where…

By integrating spatial transcriptomics with protein markers researchers have substantially improved resolution of differential gene expression analysis across tissue regions. Spatial PrOtein and Transcriptome Sequencing (SPOTS) reveals the activities of specific types of cells in much more detail than unimodal measurements. This method thus allows creation of data-rich maps of…

By Kristin G. Beaumont In cancer biology, the role of the tumor microenvironment is becoming more and more well-appreciated, not only in terms of how it contributes to the progression of disease, but in how different cellular compartments mediate response to therapy and development of therapeutic resistance. Spatial transcriptomics consists…

Many biologists seek signals of gene expression and study the structure of tissues. Sequencing RNA (RNA-seq) reveals gene expression, and techniques evolved into single-cell RNA-seq (scRNA-seq), which uncovers the gene expression in just one cell. For spatial information about organisms, scientists use microscopy. To put together these two methods, scientists…

Imagine walking into the doctor’s office in search of a diagnosis. Instead of the typical work up done today, the physician orders tests that use the local hospital’s newly acquired spatial transcriptomics platform. The next day, she delivers a diagnosis, along with a finely tuned treatment plan—both made possible because…

Research from an international collaboration shows that a single-cell omics approach can identify mutational status and characterize gene expression in hematopoietic stem cells from acute myeloid leukemia patients and successfully identify disease causing cells. Treatments exist for acute myeloid leukemia (AML), but while these often succeed initially, patients often relapse.…

Using single-cell transcriptome profiling of patients with gastric cancer, a team of researchers at MD Anderson Cancer Center has developed and validated a gene expression signature capable of predicting cancer patient survival better than other clinical features. If validated in further studies, the signature could help stratify patients with gastric…

10x Genomics said today it has acquired Spatial Transcriptomics for an undisclosed price, in a deal that maintains the buyer’s expansion mode. Based in Stockholm, Spatial Transcriptomics offers technology designed to allow RNA sequencing to perform in 2D—technology that the company says has since been adopted by customers that include…

For the first time, scientists have tracked the repair of DNA damage induced by the popular chemotherapy drug, cisplatin, at the whole-genome level in a mammal around the clock. Using single-molecule sequencing, the team of scientists lead by Nobel laureate Aziz Sancar, M.D., Ph.D., found that DNA repair of transcribed…

Sponsor: NuGEN Technologies NuGEN Technologies introduces the Universal Plus mRNA-Seq and the Trio RNA-Seq kits that enable RNA-Seq analyses from routine samples from sources like cfRNA and FFPE. Universal Plus mRNA-Seq has the option to eliminate unwanted transcripts after library construction using AnyDeplete technology to detect low expressed genes, and…

Seven Bridges said today it has invested an undisclosed amount into Spatial Transcriptomics, a startup developer of technology designed to analyze tissue samples and gene expression data in two dimensions. Seven Bridges termed the investment a first step in building a strategic partnership aimed at advancing the development of Spatial…

A team of researchers led by scientists at the Genome Institute of Singapore, and the Jackson Laboratory for Genomic Medicine (JAX) has just published data defining the cell-type composition of cancerous cells from 11 colorectal tumors, as well as adjacent noncancerous cells, a key to more targeted diagnosis and treatment.…

A team of scientists at the University of California (UC), Riverside has just published data that describes how they have targeted mosquito egg maturation at the molecular level, focusing on small regulatory RNA molecules, called microRNAs (miRNAs)—the targeting of these reproductive events could be an effective vector control strategy. The…

New research led by scientists at the Tokyo Institute of Technology provided data from real-time live-imaging of fluorescent signals derived from osteoblasts and osteoclasts of medaka fish after only one day of exposure to microgravity aboard the International Space Station (ISS). Findings from the study—entitled “Acute transcriptional up-regulation specific to…