DNA sequencing

Entire Genomes Can Now Be Assembled Quickly on a Personal Computer

An innovative bioinformatics approach developed at MIT and the Institute Pasteur allows genomes to be assembled within minutes on a standard desktop computer, a process that normally takes many hours and uses high amounts of computing power.
Inside tube of MRI scanner women receiving an MRI Scan.

Human Longevity Publishes Disease Risk, Early Detection Data

According to the study, one-in-six adults (17.3%) had at least one pathogenic genetic variant. When integrated with deep phenotyping that included imaging, blood test and other analytical methods, one-in-nine (11.9%) had genotype and phenotype associations, supporting the clinical diagnosis of a genetic disorder.
Electron microscopy virus visualization

Insights on Proteolysis May Offer New Treatments for COVID-19

Both viral and cellular proteases play a crucial role in SARS-CoV-2 replication, and inhibitors targeting proteases have already shown success at inhibiting SARS-CoV-2 in cell culture models.
Bacteriophage Virus attacking Bacterium

Combination of Bacteriophage and Antibiotic Could Be Effective Against Drug-Resistant Infection

Researchers from the Université de Montpellier, France, and the University of Pittsburgh, have generated encouraging data showing the efficacy of treating infections caused by the antibiotic-resistant bacteria M. abscessus with a bacteriophage and an antibiotic.
Colon polyps, illustration

Presence of Specific Gut Bacteria Can Increase Colon Cancer Risk

The presence of high levels of a specific strain of Bacteroides fragilis in colon polyps increases inflammation and may encourage progression to colon cancer, suggests research from the University of Washington.

Cancer Liquid Biopsy Developer Bluestar Raises $70M, Adds Venter to Scientific Advisory Board

Bluestar said the equity funding will enable it to advance its clinical development and commercialization efforts for its platform, which applies machine learning and the DNA-based 5-hydroxymethylcytosine (5hmC) biomarker as a screening method to detect cancer in multiple organs in men and women.
Comparison of CT Chest with contrast media Axial ,coronal and sagittal view for screen lung nodules and lung cancer .

Lung Cancer Risk Screening Gets Artificial Intelligence Assist

The researchers trained an algorithm on CT images of more than 16,000 nodules, including 1,249 malignancies, from the National Lung Screening Trial and validated the algorithm on three large sets of imaging data of nodules from the Danish Lung Cancer Screening Trial.

LDT Regulation Issue Rekindled with Reintroduction of VITAL Act

The VITAL Act would update federal lab standards under the Clinical Laboratory Improvement Amendments (CLIA), overseen by the U.S. Department of Health and Human Services (HHS)—through which LDTs would also be regulated under the Public Health Services Act, which gives HHS authority to respond to public health emergencies.
Intestinal microbiome, medical concept

Reaching into The Past: Lessons from The Ancient Oral and Gut Microbiome

Microbial genomic information from ancient oral and fecal samples is remarkably similar to samples from modern humans. But this research also reveals disturbing changes in the gut microbiome in modern industrialized countries, supporting the theory that the ‘disappearing human microbiome’ may contribute to chronic disease.
Centogene’s CentoMD® rare disease variant database will be integrated into Qiagen’s bioinformatics suite in a rare disease bioinformatics collaboration by the companies. [Source: alengo/Getty]

Multiomics Data Analysis Identifies Cancers’ Genetic Vulnerabilities

Gene dependency relationships, including synthetic lethality, may produce cancer ‘Achilles heels’; a Belfast-based team has designed a program to look for these vulnerabilities which was very effective at finding them in a range of different cancer cells and tissues.