investigators discover a rare genetic variant shown to protect people who carry known genetic risk factors for Alzheimer's disease

New Research Shows Why ApoE4 Increases Alzheimer’s Disease Risk

The researchers found that the lipid composition was healthy in the brain of mice with ApoE3 with sufficient amounts of unsaturated fatty acids and endocannabinoids. But when compared to the brain cells of E3, the E4 mice did not receive enough lipids.
Sick woman with Long COVID lying in bed

Gene Expression Changes Could Be Behind Long-Haul COVID-19 Symptoms

Exposure to the SARS-CoV-2 spike protein alone was enough to change baseline gene expression in airway cells in early stage research, suggesting a possible cause for long COVID symptoms.
The combination of Bristol-Myers Squibb (BMS)'s marketed cancer immunotherapies Opdivo (nivolumab) plus a low dose of Yervoy (ipilimumab) showed durable clinical benefit in a Phase II trial as a first-line treatment in patients with microsatellite instability-high (MSI-H) or DNA mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC)

Guardant Throws Hat in Early Cancer Detection Ring with CRC Test

Guardant Reveal, is a plasma-only ctDNA test for detection of early-stage colorectal cancer, with additional cancer types to follow. The minimal residue disease test, which will have a turnaround time of seven days, had been in development since 2016 under the name LUNAR-1, and was launched for research use only in 2019.
Woman aging

Elysium Health Launches At-Home Test to Measure Rate of Aging, Biological Age

Elysium Heath also announced Morgan Levine, Ph.D., of Yale School of Medicine has joined the company as head of bioinformatics to improve the testing methodology of Index, with the goal of making its application accurate and informative for individuals.
Senior Women with Gentle Smile

New Evidence for Biomarkers of Dementia and Value of Aerobic Exercise in Preventing Cognitive...

The researchers looked at whether three specific biomarkers, previously implicated in learning and memory, would increase in older adults following exercise and correlate with cognition and metabolomic markers of brain health.
Source: Martin Barraud/Getty Images

10 Countries in 100K Genome Club

These ten governments have committed funding for projects that will sequence a minimum of 100,000 citizens to spur genomic medicine
binary code pattern

The Biomarker Future is Digital

As demand continues to grow for more data to inform precision medicine, digital biomarkers represent a new class of biomarkers that provide information in real time.
Portrait of woman holding black and white younger photo of herself

Pooled Genome-Wide Data Analysis Finds Link Between Blood Iron Levels and Aging

The study combined genome-wide association summary statistics for heart disease, dementia, and cancers and identified 10 genomic loci that appear to influence all three of those phenotypes.
Portrait of a contemplative woman with cancer

Labcorp, CCORN Collaborate to Assess Factors Leading to Disparities in Cancer Care

As part of the collaboration, the two organizations will create the PREFER (PRospective rEgistry oF advanced stage cancER) patient registry to inform the development of clinical trials aimed at improving participation from diverse populations.
The Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium has launched a project designed to seek regulatory qualification of new biomarkers that predict the change in joint damage over time from osteoarthritis (OA) in the knee. [Source: American Academy of Orthopaedic Surgeons]

Consortium Seeks Regulatory Qualification of Biomarkers for Knee OA

New research plans to validate the highest performing radiographic measures, MRI measures, and biochemical markers from 2015 project