Strata Oncology and University of California
Strata Oncology and University of California

Strata Oncology said today it will partner with University of California, San Francisco (UCSF), to expand access to tumor sequencing and clinical trials for men with metastatic prostate cancer.

Strata, a precision oncology company, and UCSF are launching Stratify Prostate™, an initiative aimed at advancing precision medicine among men with advanced forms of the disease.

“Our shared goal is to provide advanced patients the opportunity to be tested without the worry of cost or location,” Strata CEO Dan Rhodes, Ph.D., said in a statement.

Through Stratify Prostate, Strata said, eligible metastatic prostate cancer patients anywhere in the United States can now access a free next-generation sequencing (NSG) test by enrolling in the Strata Trial, a Strata-sponsored observational study aimed at assessing the impact of sequencing on clinical trial enrollment.

The test, StrataNGS™, is a 90-gene targeted assay focused on actionable genetic alterations, and conducted in Strata's high-throughput CLIA-certified lab in Ann Arbor, MI. StrataNGS is designed to sequence DNA and RNA using limited archival or fresh biopsy material, as well as generate results in less than 10 business days.

Additional trials for prostate cancer targeted therapy will be evaluated for inclusion in Stratify Prostate, according to Strata.

“With innovations like Stratify Prostate and the larger Strata Trial, our aim is to establish highly efficient ways for physicians and their patients to get actionable genetic information and real-time connections to targeted therapies,” Rhodes added.

Launched in February, Strata Trial is available to patients with several forms of advanced cancer, including prostate cancer and other solid tumors and lymphomas. The trial is designed to identify candidates for targeted therapies through no-cost sequencing.

Physicians who are not affiliated with Strata Trial clinical research sites can, via Stratify Prostate, offer eligible patients with advanced prostate cancer access to tumor sequencing.

UCSF physicians and researchers are expected to play a leading role in Stratify Prostate, according to Strata, by applying insights from the initiative toward advances in prostate cancer.

The first clinical trials targeted in Stratify Prostate are TRITON2 and TRITON3, both of which are intended to assess Clovis Oncology's approved poly(ADP-ribose) polymerase (PARP) inhibitor Rubraca® (rucaparib) in metastatic castration-resistant prostate cancer.

Rubraca is indicated as monotherapy to treat patients with deleterious BRCA mutation- (germline and/or somatic) associated advanced ovarian cancer, who have been treated with two or more chemotherapies and selected for therapy based on an FDA-approved companion diagnostic for Rubraca.

In April, Clovis partnered with Myriad Genetics to apply Myriad’s BRACAnalysis CDx® test as a companion diagnostic for Rubraca.

And in February, Strata agreed to offer patient identification and enrollment for Epizyme's ongoing Phase II clinical trial of tazemetostat in patients with relapsed or refractory non-Hodgkins lymphoma (NHL).

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