Women with a history of severe preeclampsia have more markers linked to brain cell damage, inflammation, and possibly Alzheimer’s, Mayo Clinic researchers say. Their findings were presented this week at the Alzheimer’s Association International Conference in San Diego. Preeclampsia is a serious complication of pregnancy characterized by high blood pressure and kidney damage.…

Targeting PERK in smooth muscle cells can block and decrease buildup of atherosclerotic plaque in mouse models, according to a new study from researchers at UTHealth Houston. Smooth muscle cells have not been a major study focus for this disease until recently. The research was published this week in Arteriosclerosis, Thrombosis,…

Today the field of digital pathology can trace its roots to the end of the last century with the development of the “virtual microscope” by a combined team of researchers at the University of Maryland’s department of computer science and researchers in the department of pathology at Johns Hopkins University…

Obese individuals who had weight loss surgery were about half as likely to develop certain types of cancer and more than a third less likely to die from the disease than those didn’t have the procedure, according to a new study presented at the recent American Society for Metabolic and…

New longer-term results from the CheckMate 274 trial show that adjuvant immunotherapy with nivolumab after surgery and chemotherapy helped reduce cancer recurrence in patients with urothelial cancer of the bladder or other sites in the urinary tract that had invaded the muscle. This analysis showed that patients treated with immunotherapy…

A therapy for type 1 diabetes (T1D) that involves transplanting insulin-producing pancreatic islets from a donor into a recipient, but without the need for lifelong immunosuppression, has been developed by researchers at the University of Missouri (MU), Georgia Institute of Technology, and Harvard University. The technology uses a novel biomaterial…

In a study based on electronic health records (EHRs), researchers have identified six predictors that could help determine the amount of lithium individual patients with bipolar disorder need. The team also pinpointed  genetic markers that seem to influence how quickly the body eliminates lithium from its system. The work was…

54gene and its collaborators have published their first report on the project to sequence the genomes of 100,000 Nigerians spanning 300 ethnic groups. The Non-Communicable Diseases Genetic Heritage Study (NCD-GHS) led the work, which describes the team’s strategic vision and appears in Nature Genetics this week. This data will be used…

New data analysis from the Veterans Affairs Million Veteran Program (MVP) has uncovered genetic links between COVID-19 severity and certain medical conditions it can cause, including venous embolism and thrombosis, type 2 diabetes, ischemic heart disease, and neutropenia. Identifying these shared variants could improve understanding of COVID-19 and point to…

The Translational Genomics Research Institute (TGen), an affiliate of City of Hope, in association with HonorHealth Research and Innovation Institute and Systems Biology Ireland (SBI), have begun a clinical trial, testing the combination of two drugs against advanced pancreatic cancer, one of the most deadly and difficult-to-treat malignancies. The trial combines two drugs — Vemurafenib…

by Joseph Zabinski, PhD, Senior Director, AI & Precision Medicine, OM1   Sponsored content brought to you by Personalizing medicine using population-level insights can seem like a contradiction. On one hand, the goal is to better fit treatment to the individual patient, moving away from generalized approaches toward a “one…

By studying cancer from a network-based perspective rather than a collection of single genes, researchers from Clemson University have characterized uterine cancers in a new way. “Looking at the whole network of genes involved in uterine cancer rather than a variety of single candidate genes will hopefully lead us to…

Research led by the University of California San Francisco (UCSF) shows that dividing patients according to their individual immune profiles or ‘archetypes’ could result in better responses to cancer immunotherapy than current practice. Immunotherapy has revolutionized the field of oncology, but it is more effective for some patients than others.…

A novel immunotherapy strategy that generates transient engineered chimeric antigen receptor (CAR) T-cells in the body can reduce scarring and restore cardiac function in a mouse model of heart failure, according to research led by the University of Pennsylvania. The experimental immunotherapy approach is based on the delivery of modified…

Digital biology drug discovery company Recursion has secured a commitment of up to $12 billion from Roche and its Genetech subsidiary to apply its Recursion Operating Systemt (OS) to advance therapies across 40 program that include neuroscience and an undisclosed oncology indication the companies announced today. Recursion OS applies machine…