A type of medication developed for treating diabetes could be also be effective for treating all patients with heart failure, according to researchers from the University of East Anglia. Sodium-glucose co-transporter-2 (SGLT2) inhibitors were first approved to treat type 2 diabetes in 2012 and their main mechanism of action is…

Cell culture studies by researchers at the University of Liverpool and Institut Pasteur in Paris suggest COVID-19 can be targeted using existing drugs. The new findings, published in Nature Communications, examine proteolysis during viral infection, and may help pinpoint targeted treatments against the virus. SARS-CoV-2 has been responsible for more than 227 million…

A humanized mouse model that mimics a patient’s immune system is better than current approaches for identifying an optimal living organ donor, according to scientists at the Medical College of Georgia (MCG) in Augusta, USA. They call their approach an “immunobiological algorithm” that provides a comprehensive prospective on how a…

Originally named the Gene Security Network, clinical molecular testing company Natera was founded in 2004 by Jonathan Sheena and Matthew Rabinowitz. Both of the co-founders came from outside the life sciences industry: Sheena from mobile search engine technology company PhoneSpots, which pioneered the ‘send to mobile’ feature, and Rabinowitz at…

Sponsored content brought to you by   What is the mission of Precision Biomarker Laboratories (PBL)? Jennifer Van Eyk, PhDDirectorPrecision Biomarker Labs Precision Biomarker Laboratories is focused on releasing the power of precise proteomics by utilizing our growing understanding of the proteome to transform how medicine…

Adela, the developer of a liquid biopsy that spun out of Toronto’s University Health Network last year under the name DNAMx, has renamed itself and formally launched with a $60 million Series A financing. Proceeds from the financing are intended to support advancing its blood test towards commercialization, with initial…

BK virus (BKV)-specific T cells from healthy donors were safe and effective as an off-the-shelf therapy for BKV-associated hemorrhagic cystitis (BKV-HC), according to a Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center.  BK virus-associated hemorrhagic cystitis is a painful complication and common after…

A large collaboration of U. S. scientists, led by the Broad Institute, has created a single cell atlas to represent the impact severe COVID-19 can have on different cell types around the body. They hope that by collating this information and allowing other researchers to access it that it will…

Researchers from Mount Sinai have shown that genetic ancestry can be used to better understand and predict who is more susceptible to certain disorders—including cancers, asthma, diabetes, and cardiovascular disease. They point out that this information could be used to develop early interventions. Their study was reported in the journal Cell.…

Research continues to find that the effects of COVID-19 may linger long after hospital discharge. In the latest study, researchers from in England found increased rates of organ damage, or multiorgan dysfunction, in a study of patients discharged from NHS hospitals after COVID-19. Published in The BMJ, the risk for…

A team of researchers based at the Children’s Hospital of Philadelphia found that a common nutritional supplement can reduce the risk of fatal stroke in people with the rare genetic disorder called hereditary cystatin C amyloid angiopathy (HCCAA). HCCAA is part of a group of diseases in which amyloid proteins…

A drug regimen that combines VEGFR inhibitor drugs with a peptide, angiotensin-(1,7), which is generated by the ACE2 enzyme, can overcome treatment resistance and improve survival in mice with the common kidney cancer renal cell carcinoma (RCC), according to a team of researchers from the U.S. and Ireland. The team’s…

In encouraging news regarding melanoma therapy, researchers found that a personalized vaccine continues to keep cancer cells in check four years after patients received it. In a Phase 1 study among eight patients with advanced melanoma who received the NeoVax vaccine, after a median of four years, all of the…

To protect our bodies from cancers such as melanoma, the immune system uses a monitoring system called immune surveillance that detects and destroys premalignant or malignant cells in the body. However, the immune system can have an alter ego at times, favoring tumor development instead of destroying the premalignant or…

Researchers headed by a team at the University of California, San Francisco (UCSF) carried out experiments in a dual tumor mouse model, have pinpointed regulatory pathways that are inhibited when liver metastases have developed. The results showed that the presence of tumor antigen in the liver not only compromised immunity…