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Published on December 22, 2020
Researchers at the Institute for Research in Biomedicine (IRB) in Barcelona, and a team at the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association in Germany have analyzed clinical data to show that colon cancer patients whose tumors have a large amount of the Mll1 protein have…
Published on June 5, 2020
Early-stage diagnostics developer Prescient Metabiomics announced this week it has entered a research collaboration with the Harvard T.H. Chan School of Public Health dedicated to study microbial biomarkers to identify the presence of precancerous adenomas and carcinomas in the colon. The initial collaboration will apply statistical and bioinformatic techniques for…
Published on December 12, 2019
Precision medicine has advanced cancer treatment dramatically, and patients with metastatic colon and rectal cancer can achieve significant benefits when clinicians genotype tumors and use the data to guide therapy. Targeted therapies and immunotherapies have been shown to improve clinical outcomes. For example, anti-EGFR therapies are commonly used in treating metastatic…
Published on November 26, 2019
A new study by Rutgers University researchers suggests that two genes expressed in the intestinal cells that line the inside of the colon may also be involved in cancer development. Recent studies have shown that intestinal stem cells can increase in animals on a high fat “Western” diet, potentially explaining…
Published on April 29, 2019
Colon cancer ranks third in prevalence and fourth in cancer deaths among all cancers worldwide. However, due to its extreme heterogeneity, progress has been slow towards precision diagnostics and treatments. The National Cancer Institute’s Proteomic Tumor Analysis Consortium, led by researchers at Baylor College of Medicine, embarked upon a mission…
Published on May 31, 2018
The chemical triclosan is used as an antimicrobial agent in more than 2000 consumer products, from toothpaste and cosmetics to kitchenware and toys. Studies in mice by a team of scientists in the U.S. and China have now linked short-term dietary exposure to triclosan with altered gut microbiota, colonic inflammation,…
Published on May 18, 2018
Long noncoding RNAs (lncRNAs) are, as the name suggests, long transcripts of RNA that do not code for proteins, but have been found to regulate a wide range of cell functions. Scientists at Case Western Reserve School of Medicine have now discovered that one lncRNA, designated lincDUSP, may play a…
Published on April 4, 2016
Understanding the molecular mechanisms that bring about aberrant protein glycosylation is critical to uncovering the pathways that contribute to overall tumor progression. Little is known about the molecular basis of altered protein glycosylation, which is often the hallmark of many human cancers including colorectal cancers (CRC). Now, a new study…
Published on February 25, 2015
Selah Genomics, a subsidiary of EKF Diagnostics, entered an 18 month collaboration with Greenville Health System (GHS), DecisionQ, and Becton Dickinson and Company (BD). The goal of the alliance is to unite clinical annotations with next-generation sequencing (NGS) technology and artificial intelligence-based algorithms in hope of improving clinical decision making…
Published on January 29, 2018
Benjamin Weinberg, M.D., of the Georgetown Lombardi Comprehensive Cancer Center has been awarded $125,000 by the Colorectal Cancer Alliance (CCA) to study differences in the colon microbiota between younger and older patients with colorectal cancer (CRC). The funding is part of CCA’s Chris4Life Research Program which focuses on young-onset CRC.…
Published on March 26, 2024
A single mutation in MUTYH, a gene known to cause colorectal cancer, may cause other solid tumors, according to a study of over 350,000 patient biopsy samples conducted by researchers at the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins Bloomberg School of Public Health, and Foundation Medicine. Their findings…
Published on March 13, 2024
The majority of adults who have survived childhood cancer are not up to date with potentially life-saving surveillance screening tests to check for delayed effects of their initial treatment, Canadian research suggests. The study, which included data for 3241 individuals diagnosed with cancer at one of Ontario’s five pediatric cancer centers…
Published on March 6, 2024
Scientists at the University of California, San Francisco, have found a way to target K-Ras-G12D mutations, which are especially prevalent in pancreatic ductal adenocarcinoma. This marks an important breakthrough as K-Ras mutations are were considered until recently, to be all but undruggable. But ever since the arrival of sotorasib and…
Published on February 28, 2024
A new study by researchers from the Massachusetts Institute of Technology (MIT), the Dana-Farber Cancer Institute, Harvard Medical School, and elsewhere describes a strategy in which early-stage cancer cells manage to evade immune system surveillance. Early in colon cancer development, cells turn on a gene called SOX17 that can become…
Published on February 28, 2024
A new study led by researchers at Radboud University Medical Center in the Netherlands has shown that artificial intelligence (AI) can significantly improve the outcome of colonoscopies. With the help of an AI-powered computer, doctors were able to detect 37 percent more adenomas per colonoscopy in the same amount of…