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Published on November 8, 2023
Research published today in Nature Communications, from investigators at Perlmutter Cancer Center at NYU Langone Health, says that genetic information from healthy tissues near lung adenocarcinoma tumors may better predict cancer recurrence after initial treatments. Adenomcarcinoma accounts for roughly one-third of all lung cancer in the United States according to…
Published on November 2, 2023
The American Cancer Society (ACS) released an update of its lung cancer guideline this week expanding the number of people recommended for screening to several million. The new guideline recommends yearly screening for people aged 50 to 80 years old who smoke or formerly smoked and have a 20-year or…
Published on October 4, 2023
A simple model, developed by U.K. researchers using machine learning, can accurately predict lung cancer risk and identify people who need screening using just three variables— age, smoking duration, and pack–years. The University College London lung cancer death (UCL-D) and incidence (UCL-I) models performed as well as or better than…
Published on August 31, 2023
The location of cytotoxic T cells, in and around tumors, may help predict lung cancer patient survival and treatment response, according to work from University of Edinburgh researchers. Their findings, they say, could help to pave the way for improved immunotherapies. Such treatments are revolutionary in their ability to cure…
Published on August 9, 2023
Topline results from the late-stage LIBRETTO-431 study evaluating the efficacy of Eli Lilly’s oral targeted cancer therapy Retevmo (selpercatinib) in participants with advanced or metastatic rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC), show increased progression free survival compared to treatment with a PD-1 inhibitor plus chemotherapy. The…
Published on July 26, 2023
Researchers from the University of Southern California have discovered how lung cancer cells under stress can change the role of a protein to promote growth of and metastasis of these cells. The protein, called CRP78, can play a similar role in cells under stress in other diseases as well including…
Published on July 12, 2023
A new study from researchers at the Mass General Cancer Center has uncovered a protein that is implicated in lung cancer resistance to tyrosine kinase inhibitor (TKI) therapies. The research, published Wednesday in Nature suggest the protein, APOBEC3A, could be a promising target for therapeutic development. “Traditionally, we treat patients…
Published on June 14, 2023
Eating a more substantial meal led to significantly higher blood concentrations of drug in patients taking an often-prescribed treatment for lung cancer. Alectinib (Genentech’s Alecensa) is a small molecule kinase inhibitor used to treat ALK positive, metastatic, non-small cell lung cancer. Taking a dose of alectinib with a small, low-fat…
Published on June 5, 2023
AstraZeneca notched another win with its tyrosine kinase inhibitor Tagrisso (osimertinib) in early-stage, non-small cell lung cancer. In the ADUARA trial, overall survival (OS) was doubled with Tagrisso compared to placebo. The trial comprised patients with epidermal growth factor receptor-mutated (EGFRm) positive tumors who were treated after surgery. The final…
Published on May 4, 2023
An alliance between the American Lung Association (ALA) and Gateway for Cancer Research, a nonprofit organization funding early phase clinical trials, will provide $678,000 of funding for a five-year vaccine trial targeting small cell lung cancer (SCLC). The trial, which began enrolling patients last spring is led by Jeffrey Ward,…
Published on May 3, 2023
Originally Aired: May 18, 2023Time: 8:00 am PT, 11:00 am ET, 17:00 CET VIEW NOW SHORTLY To be implemented in the clinic, tests must be validated and approved through a regulatory process. Coverage and procedures for mutation types vary among the many available tests. There are various methods for EGFR mutation detection,…
Published on April 26, 2023
New research reveals a mechanism explaining why natural kills (NK) cells, known to have a major role in eliminating cancer cells, become ineffective in lung cancers. Researchers from the Icahn School of Medicine at Mount Sinai show that the immune-system molecule TREM2, expressed on macrophages, inhibits the number and efficacy…
Published on April 19, 2023
Pre-surgical immunotherapy and chemotherapy followed by post-surgical immunotherapy significantly improved event-free survival (EFS) and pathologic complete response (pCR) rates compared to chemotherapy alone for patients with operable non-small cell lung cancer (NSCLC). Those were the results of a Phase III trial presented by researchers from the University of Texas MD…
Published on April 12, 2023
Lung cancer is the second most commonly diagnosed cancer worldwide, after breast cancer, with over 2.2 million new cases recorded in 2020 by the World Health Organization’s International Agency for Research on Cancer. It also accounted for nearly 1.8 million deaths in that year, making it the leading cause of cancer…
Published on March 29, 2023
Researchers at Academia Sinica, National Yang Ming Chiao Tung University, National Taiwan University Hospital, and National Taiwan University, have shown how blocking the activity of fibroblasts can help to treat lung cancer. The team’s studies found that efficacy of the anticancer drug cisplatin was increased when treatment was combined with…