A team of researchers led by investigators at the University of California, San Diego (UCSD), have identified a collective signature of proteins and metabolites that lab tests indicate can predict with exceptional accuracy the likelihood of death resulting from bacteremia (SaB)—a bacterial infection in the blood that kills 20–30% of…

Burlingame, CA-based Humanigen is testing whether its engineered antibody or “Humaneered” technology developed over two decades can catapult the company to a leading role in the scramble to conquer COVID-19. This coming four years since its emergence from a bankruptcy, touched off by the arrest of its former CEO, “Pharma…

An international team of researchers has developed a new genetic risk score that could dramatically improve screening for osteoporosis. The team, which includes scientists from the University of Sheffield, developed the gSOS scoring system based on clinical information from more than 340,000 individuals who donated health data to the UK…

Once an ecosystem is disturbed, restoring it can be difficult. And when the disturbed ecosystem is a patient’s microbiome, restoring the patient to health can be even more difficult. Just one ecosystem element that proliferates or diminishes beyond bounds may throw multiple elements into disarray, creating a dysbiosis that resists…

Clinical laboratories are showing signs of rallying after the recent slump in activity due to COVID-19, according to a new study from Arlington, Va.-based Kalorama Information, an in vitro diagnostics market research firm. The study, released June 25, found labs are running more tests and a greater variety of them…

Researchers from an NIH-funded consortium are preparing to recruit nearly 2,600 participants whose data will be incorporated into maps of the molecular changes to the human body wrought by exercise—maps that may lead someday to greater use of personalized exercise regimens or exercise-mimetic drugs for people unable to exercise. The…

Chimeric antigen receptor (CAR) T cells are best known for their role in treating blood cancers. When used as an anticancer treatment, T cells are removed from an individual and engineered to boost their ability to target cancer cells before being returned to the body. The altered immune cells then…

Hepatocellular carcinoma (HCC) is the most common type of liver cancer with incidence and mortality rates rising globally. Often caused by previous viral infections from hepatitis B and hepatitis C, HCC detection early in the course of disease remains less than optimal. To improve early diagnosis, researchers from the National…

US researchers have analyzed the available literature on COVID-19 infections to assess factors linked with severe cases and to inform medical professionals about drugs that could be repurposed to treat the disease. Since the end of 2019, the SARS-CoV-2 virus behind COVID-19 has spread across the globe in a way…

Scientists at the Wellcome Sanger Institute, Open Targets, Biogen, GSK, and their collaborators say they have found that T cells responded differently to immune signals the more “training” they had been exposed to, rather than being a simple switch from naïve to experienced. This could help guide research into finding…

Researchers believe a combination of health factors and type II diabetes puts some patients at a higher risk than others for suffering more severe effects of COVID-19. A new study from the National Institute of Health (NIH) may explain why certain populations in the US are more prone to develop…

While Previous reports of which medications may influence COVID-19 symptoms and outcomes of patients have been reported on a case-by-case basis, a recent study of more than 1,000 COVID-19 positive patients from China suggests that ACE inhibitors and angiotensin receptor blockers may actually increase the risk of severe COVID-19 complications.…

As the market for immunotherapies grows, reaching over $10 billion already, the interest in biomarkers to guide prescribing has intensified. Doctors want better ways to predict who will benefit from the drugs. “We need to protect patients from unnecessary risk of side effects from drugs that can’t help them and…

For patients admitted to the hospital and confirmed to have the new coronavirus disease (COVID-19), the key risk factors for death are: Advanced age Signs of sepsis Blood clotting issues These risk factors come from a new retrospective study that evaluated data records for 191 patients—137 survivors and 54 non-survivors.…

A University of Sydney-led research team has employed a multi-omics approach using state-of-the-art analytical tools to understand how intermittent fasting impacts on the liver to help prevent disease. The results revealed that every-other-day-fasting (EODF) in mice impacted fatty acid metabolism, and was associated with inhibition of the transcription factor HNF4a,…