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Published on August 25, 2016
A collaborative study from investigators at McMaster University in Canada and Boston University presents evidence showing that people with high levels of four biomarkers in the blood may be more likely to develop a stroke than people with low levels of the markers. The new study was published recently in…
Published on April 1, 2024
A population-based study from Sweden indicates that children and teenagers who were overweight or have obesity are more likely to have high blood pressure in later adult years from 50 to 64 years of age. The research, to be presented at the upcoming European Congress on Obesity (ECO) next month…
Published on April 1, 2024
The adult human brain is made up of billions of neurons and glial cells. Understanding the diversity of these cells and their distinctive gene-regulatory mechanisms is crucial for determining how the brain works and, in turn, for developing treatments for neurologic disorders. Until recently, cell populations were defined based on…
Published on March 20, 2024
SARS-CoV-2, the virus that causes COVID-19, can damage the heart in patients with ARDS (Acute Respiratory Distress Syndrome) without directly infecting heart tissue, a new study has found. These findings suggest it is systemic inflammation that causes this damage. “The research also suggests that suppressing the inflammation through treatments might…
Published on March 11, 2024
Novo Nordisk has just taken two big steps toward cementing its lead in the weight loss treatment market. Late last week, the FDA approved a new label expansion for Wegovy (semaglutide), and just before that the company released promising early trial results for its experimental weight loss pill, amycretin. Patients…
Published on March 6, 2024
An RNAi-based treatment helps control blood pressure for several months in patients who are on standard of care, according to new Phase II trial results. Roche and Alnylam’s zilebesiran is given as a single injection and its long-lasting effects could be a boon, especially in patients whose blood pressure is…
Published on February 14, 2024
Common cardiovascular-related pregnancy complications may result in worse future heart health for the child as well as the mother, a new study suggests. This large, collaborative study found signs of higher risk of cardiovascular disease and stroke in about half of children born after a pregnancy that featured hypertension or…
Published on February 12, 2024
Already a popular topic, the launch of the large language model-based chatbot, ChatGPT, at the end of 2022 increased excitement around artificial intelligence (AI) in the media to fever pitch. This event triggered many heated debates about the technology and its numerous potential applications over the past 12 months. There…
Published on February 12, 2024
ol.custom-marker { counter-reset: list;}ol.custom-marker > li { list-style: none; counter-increment: list;}ol.custom-marker.parens-after.decimal > li::marker { content: counter(list) “)\a0”;} By Michael N. Liebman Biology embraces the existence of a central dogma, i.e., DNA → RNA → protein, and drug development has embraced its own, i.e., disease → target → drug, but both…
Published on February 7, 2024
Sickle cell disease (SCD) will be the first focus of the U.S.’s new Cell and Gene Therapy (CGT) Access Model, which aims to increase access to cell and gene therapies for vulnerable populations. Gene therapies are some of the most expensive treatments in the world. The Centers for Medicare &…
Published on January 18, 2024
A large-scale data analysis suggests about a quarter of dementia cases are linked to race or controllable risk factors, such as high blood pressure, diabetes, physical inactivity, and too little or too much sleep. Adding gene variant APOE ε4 status to the analysis boosted the number of explainable cases to…
Published on December 28, 2023
A new class of drugs have been synthesized, which could address a long-standing pharma challenge—cyclic peptides that can be given orally. A team from École Polytechnique Fédérale de Lausanne (EPFL) has generated such cyclic peptides that can target thrombin. The study was published in Nature Chemical Biology, by scientists from the…
Published on December 28, 2023
Researchers from the University of Exeter in the U.K. and Maastricht University in the Netherlands have identified 15 risk factors associated with young-onset dementia, challenging the prevailing belief that genetics are the sole culprit, paving the way for innovative prevention strategies. Young-onset dementia, a term describing the development of dementia…
Published on December 27, 2023
New research from investigators in the U.K. has shown that markers of brain injury are present many months after COVID-19 infection, despite standard blood testing that is normal. The research, published in Nature Communications, helps provide potential therapy pathways for patients that experience cognitive difficulties after recovering from COVID-19 by…
Published on December 1, 2023
The American College of Cardiology (ACC) and the American Heart Association (AHA), in collaboration with other medical associations, have released a new comprehensive guideline for the prevention and management of atrial fibrillation (AFib). Published simultaneously in the Journal of the American College of Cardiology and Circulation, the guideline addresses how…