Regeneron Genetics Center (RGC), a subsidiary of Regeneron Pharmaceuticals, announced it will collaborate with GlaxoSmithKline (GSK) and UK Biobank to generate genetic sequence data from the health database's 500,000 volunteers participants, with the aim of providing new genetic evidence to researchers in developing new therapeutics across a broad range of…

A team of investigators lead by researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, along with their African collaborators from the University of Nigeria and University of Ghana Medical School have assembled data from a genome-wide association study (GWAS) that was searching…

Investigators from the Lund University Diabetes Centre in Sweden have been able to map the entire methylome in the insulin-producing pancreatic islets, measuring individual gene function and expression. The findings from this study were published recently in Diabetes through an article entitled “Whole-genome Bisulfite Sequencing of Human Pancreatic Islets Reveals…

Researchers at The University of Texas Health Science Center at Houston (UTHealth) have just developed a framework to understand how whole genome sequence (WGS) data can be analyzed to identify genetic variations that raise or lower risk of disease. The findings from this new study were published recently in the American…

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have recently identified 10 new possible combination therapies to treat breast cancer based using an in silico method to analyze cell signaling networks and 64 known drug pairings currently used to treat the disease, according to an advance publication of…

Nonprofit genomic analysis organization the Translational Genomics Research Institute (TGen) and California-based City of Hope have announced a collaboration to apply genomic research toward clinical practice through a partnership in which TGen will become a City of Hope subsidiary. The partnership aims to combine TGen’s expertise in genomic analysis and…

The International Phenome Centre Network (IPCN), a worldwide consortium of research centers focused on disease prevention, detection and treatment by better understanding the dynamic interactions of our genes and our environment in the development and progression disease, launched November 29 with the goal of tackling pressing global health challenges including autism,…

At the American Society of Human Genetics (ASHG) 2016 Annual Meeting in Vancouver, B.C., researchers from Harvard Medical School, the Broad Institute, and Brigham and Women's Hospital (BWH) presented data of a large-scale, genome-wide analysis of more than 110,000 samples. The researchers reported that the data, which had been collected by the…

Scientists at Johns Hopkins University believe they are closer to understanding the genetic mechanism of a rare, complex, multiple-gene disorder called Hirschsprung's disease. The results from the latest study—entitled “Enhancer Variants Synergistically Drive Dysfunction of a Gene Regulatory Network In Hirschsprung Disease” and published in Cell—suggest that many patients develop…

A new large-scale study involving more than 160 international researchers from 17 countries—members of the Early Growth Genetics (EGG) Consortium—and led by investigators from University of Exeter Medical School have identified key genetic differences that may help explain why some babies are born bigger or smaller than others. The new…

An international collaboration led by researchers at the University of Leicester has developed a new genetic risk score that could help identify individuals at risk of coronary heart disease (CHD) much earlier, and potentially improve its prevention. The new study—“Genomic prediction of coronary heart disease”—was published recently in the European…

Understanding how the gut microbiome is established and by what means the combination of microbes in individual children may contribute to the risk of developing conditions like type 1 diabetes and inflammatory bowel disease is key to overall developmental health. Now, a research team led by investigators at Massachusetts General…

Researchers and physicians are increasingly learning that medical interventions can be more successful when they are tailored to the particular profile of the individual patient. Yet, defining that profile has proven tough, as it involves information on an individual’s genome, proteins, fats, and variety of other biomolecules that constitute the …

The overwhelming majority of Parkinson’s disease (PD) and Alzheimer’s disease cases that occur are sporadic—caused by a complex mix of environmental and shared genetic factors. These types of interactions are notoriously difficult for scientists to study, which is why most research has focused on familial cases that have much clearer…

In 1956, Francis Crick—co-discoverer of DNA’s helical structure—postulated what is now considered to be a central doctrine of the biological sciences stating that “The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred back from protein to…