A collaboration with researchers at the Jacobs School of Medicine and Biomedical Sciences at the University of Buffalo (UB) and the Icahn School of Medicine at Mount Sinai, has produced findings supporting the hypothesis that a common genomic pathway lies at the root of schizophrenia. The results of this new…

A collaborative team of researchers led by scientists at the German Centre for Cardiovascular Research (DZHK) discovered that nearly half of all hereditary risk factors for coronary artery disease are also associated with entirely different diseases, such as schizophrenia, chronic inflammatory bowel disease, or migraines. This new study, published in…

A new Frost & Sullivan report identifies seven drivers likely to propel personalized medicine growth over the next eight years—as well as eight challenges that the field must surmount in order for the paradigm to deliver on years of promises that it will revolutionize medical diagnosis, treatment, and practice. “Global…

Genomind said today it has completed an $11 million financing with existing shareholders as well as Silicon Valley Bank. “This financing will further fuel Genomind's expansion,” Genomind President and CEO Michael Koffler said in a statement. Based in King of Prussia, PA, Genomind is a developer of genetic tests designed…

Researchers at University of California San Diego (UCSD) School of Medicine have identified six loci or regions of the human genome that are significantly linked to personality traits. Findings from this new study, which were published recently in Nature through an article entitled “Genome-wide analyses for personality traits identify six…

Scientists at Johns Hopkins University have utilized next-generation sequencing methods to identify 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder (BD). The investigators say their study—“Exome Sequencing of Familial Bipolar Disorder”—which recently published in JAMA Psychiatry, is one of the first to…

Complex neurological disorders, such as autism, schizophrenia, and bipolar disorder (BD) are the likely result of the influence of both common and rare susceptibility genes. While common variation has been widely studied over the past several years, rare variant elucidation has only recently become possible through the use next-generation sequencing…

Effectively putting the genome on the couch, a team of medical researchers and psychologists has identified genetic variants associated with subjective well-being, depression, and neuroticism. This investigation of behavioral genetics was unusually fruitful mainly because it was so wide-ranging. More than 190 scientists conducted genome-wide association studies (GWAS), and they…

Thousands of genetic variants have been associated with different diseases, but these variants still retain their most treacherous secrets—the mechanisms by which they contribute to disease processes. The trick is these mechanisms typically involve multiple conspirators—not just genes, but also transcription factors, enhancers, and promoters. If these networks could be…

Averages shout, and individuals whisper. That, in a nutshell, is the frustration of single-cell transcriptomics. Although innumerable cell types have unique gene-expression profiles, they are hard to discern. Great, thundering herds of cells typically give up their RNA to be sequenced all in one batch. It is possible to effectively…