A new report shows women are still underrepresented in clinical trials despite guidelines and laws requiring better representation set down 30 years ago. The findings come from the American College of Cardiology Cardiovascular Disease in Women Committee and are published in the Journal of the American College of Cardiology. They…

A gene mutation in the cystic fibrosis gene may explain why some people with Duchenne Muscular Dystrophy (DMD) experience cardiac problems at an earlier stage to others according to research from the University of Texas Southwestern Medical Center, which could help clinicians to better personalize treatment for these patients. DMD…

Ten years after starting the project, the Human Proteome Organization (HUPO) has completed a 90.4% read of the human proteome, knowledge essential for diagnosing and treating many human diseases and for advancing a more personalized approach to medicine. The Human Proteome Project was launched in 2010, 10 years after the…

US researchers have analyzed the available literature on COVID-19 infections to assess factors linked with severe cases and to inform medical professionals about drugs that could be repurposed to treat the disease. Since the end of 2019, the SARS-CoV-2 virus behind COVID-19 has spread across the globe in a way…

European research shows that men with heart failure have higher levels of a protein called angiotensin converting enzyme 2 than women, which could increase their risk for coronavirus infection. Angiotensin converting enzyme 2 (ACE2) is a common target for cardiovascular disease therapies, as it plays a role in regulation of…

Once ovarian cancer cells slough off from their site of origin, they tend to find a new home in tissues with high fat content. Now, researchers have shown that those ovarian cancer cells use fats as an energy source. At the heart of the transition to fatty acid metabolism is…

Researchers at Harvard may have discovered the molecular basis that can lead to cardiomyopathy in patients, as well as a new drug to treat this genetic conditions. Cardiac cells, also known as cardiomyocytes, are unique muscular cells in the body, in that they will repeatedly contract, without rest, over the…

Cleveland Clinic said today it is partnering with Owlstone Medical to establish a new center focused on studying the detection of diseases ranging from chronic conditions to cancer by measuring volatile organic compounds (VOCs) in exhaled breath, in combination with other non-invasive biomarkers from other bodily fluids such as saliva…

Renovacor, a preclinical-stage gene therapy company, has announced the successful completion of an $11 million Series A financing co-led by Novartis Venture Fund, Broadview Ventures, and BioAdvance, which were joined by New Leaf Venture Partners and Innogest Capital. Proceeds from the financing will help advance the company’s first-of-its-kind gene replacement…

Owlstone Medical, has announced a strategic collaboration with Switzerland-based Actelion Pharmaceuticals Ltd, leader in pulmonary arterial hypertension (PAH), to discover and validate a breath-based test to help facilitate the early diagnosis of pulmonary hypertension (PH) and its subtypes. Terms of the deal were not disclosed but the entire program will…

Precision medicine developer MyoKardia said it will partner with 23andMe to create a digital community designed to enable patients to access information and research opportunities in hypertrophic cardiomyopathy (HCM). Through their collaboration, whose value was not disclosed, the companies plan to launch next year a community designed to improve understanding…

An international team of researchers has discovered a single gene mutation that slows the metabolism of sugar in the gut providing people with the mutation protection against diabetes, obesity and heart disease. The finding suggests potential therapies that could mimic this mutation to treat people with these conditions. “We’re excited…

Researchers from Imperial College London and the University of California San Diego School of Medicine say they have developed a blood test that can accurately identify Kawasaki disease (KD), an acquired childhood heart disease that can result in heart attacks, congestive heart failure, and death. The research published in JAMA…

When President Obama announced the Precision Medicine Initiative at the State of the Union in 2015, it recognized more than a decade of work that scientists and medical researchers had already committed to identifying the underlying genetic causes of diseases and specific pathways to treatment. To date, there have been…

Sangamo Therapeutics said today that the first patient in the Phase I/II CHAMPIONS clinical trial has been treated with its in vivo genome editing candidate therapy SB-913 for mucopolysaccharidosis type II (MPS II), also called Hunter syndrome. “We are at the start of a new frontier of genomic medicine,” declared…