VIEW NOW   Broadcast Date: October 13, 2023Time: 8:00 am PT, 11:00 am ET, 17:00 CET Three-dimensional (3D) cultures such as spheroids and organoids are an important part of the research model market, helping to close the gap between cell cultures and animal models. Both organoids and spheroids have been used to…

A novel method to bioprint miniature tumor organoids was developed by scientists from the UCLA Jonsson Comprehensive Cancer Center. The method will allow researchers to study and analyze individual organoids in great detail, which could help identify personalized treatments for individuals with rare or hard-to-treat cancers. The research team reported…

Since most head and neck cancer patients relapse, and there is strong evidence that subtypes exist, there is an urgent need for biomarkers to guide treatment. Now, researchers have developed a biobank of over 100 organoids, which may help clinicians choose the most appropriate treatment. These patients typically undergo surgery,…

Patient-derived tumor organoids—3D tissue cultures derived from tumor tissue samples—could be used to predict the most suitable treatment for patients with biliary tract cancer, suggests research presented at Digestive Disease Week 2023 in Chicago. Biliary tract cancers are relatively uncommon (around 8000 people in the United States are diagnosed with…

Scientists at the Princess Máxima Center for pediatric oncology and Hubrecht Institute in the Netherlands report organoids and CRISPR-Cas9 allowed them to better understand the tumor biology and biological consequences of different DNA changes of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer. The findings are published in Nature…

Seed-sized brain-like organoids that are reminiscent of one wrinkle in the human brain 15 to 19 weeks post-conception were created and grown in the lab by University of Utah (U of U). The organoids are being used to help scientists understand structural differences in the human brain that may contribute…

Originally Aired:  June 27, 2022Time: 8:00 am PT, 11:00 am ET, 17:00 CET VIEW NOW In this Learning Lab, we discussed the development of respiratory airway and alveolar organoids derived from human iPSCs and how these are used in modeling respiratory diseases such as cystic fibrosis. Airway organoid models can be used…

University of California, San Diego (UCSD), School of Medicine scientists used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. The scientists used gene therapy  tools to recover the gene’s function. Their study is published in Nature Communications. “Transcription Factor…

Stem cell scientists have created fallopian tube-based organoids that may help predict which individuals with BRCA-1 mutations will develop ovarian cancer years or even decades in advance, and could be used to develop personalized therapies.   Their study was published this week in Cell Reports. Clive Svendsen, Ph.D., professor of…

Wake Forest researchers and clinicians are using patient-specific tumor ‘organoid’ models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer. One of the rarest cancers, this malignancy affects only 1 in 100,000 people. The study was published this week in Clinical Cancer Research. The lead author is…

Researchers at Boston University have created human induced pluripotent stem cells (iPSCs)-derived intestinal organoids that can be infected with SARS-CoV-2. How the virus affects the gut, the researchers say, can potentially serve as a way to evaluate novel therapeutics for COVID-19. They report that SARS-CoV-2 productively infects both proximally—and distally—patterned…

To understand the molecular interplay between the SARS-CoV-2 virus and human tissue, particularly host responses to infection, researchers from the University of California San Diego School of Medicine developed lung and cerebral organoids. When challenged with form of the virus, the organoids’ responses mimicked those found in natural organ tissues…

Researchers at the Austrian Academy of Sciences have applied a new tissue screening technology is calls CRISPR-LICHT (CRIPSR-LIneage tracing at Cellular resolution in Heterogenous Tissue) to identify 25 out of 173 candidate microencephaly genes linked to the rare neurological condition, which is characterized by abnormal brain development and reduced head size. Previously, 27…

Researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM) have released new study findings that show promise for developing a patient-specific tumor organoid platform to improve immunotherapy treatment selection for patients. “Immunotherapy drugs are not inexpensive, and it is not uncommon for the cost of therapy to be measured…

Data from a team of Australian researchers shows the potential of a new therapeutic strategy for treating castration-resistant prostate cancer (CRPC), the most aggressive form of the disease. The research, published in the British Journal of Cancer, studied the role of Cyclin-Dependent Kinase 9 (CDK9) in the progression of aggressive…