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Published on January 25, 2023
Scientists have discovered a new drug target for Ewing sarcoma, a protein known as ETV6, which is widely found in all cells, including normal cells. Known to have some function in hematopoietic cell development, its function in cancer has remained mostly unknown. Using human sarcoma cells, researchers from the Cold…
Published on August 30, 2023
New research by scientists at Cold Spring Harbor Laboratory demonstrates differentiation therapy as a new treatment option for Rhabdomyosarcoma (RMS), a rare type of cancer that forms in soft tissue. RMS can occur at any age, but it most often affects children. Treatment usually involves chemotherapy, surgery, and radiation procedures.…
Published on June 3, 2021
Researchers based at the University of North Carolina at Chapel Hill have discovered that the gene OTUD7A controls a cancer-causing protein in Ewing sarcoma, a type of bone cancer mostly impacting children. The team also uncovered a compound that appears to be able to block the activity of the OTUD7A…
Published on March 2, 2023
Investigators at Children’s Hospital Los Angeles (CHLA) have developed a liquid biopsy for solid tumors that could help deliver a specific diagnosis when a tissue biopsy is not feasible. The test looks at cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions. The first…
Published on August 25, 2020
A team of investigators at the Children’s Hospital of Philadelphia (CHOP) has released new data describing an enhanced treatment that leads to long-term remissions in 80–100% of mice with drug-resistant or high-risk solid tumors. Findings from the new study were published recently in Cancer Research through an article titled, “Structural Optimization…