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William Haseltine

The Dawn of Next Generation COVID-19 Vaccines

Over time people will inevitably get tired of needing two or three booster shots a year. Vaccine uptake will dwindle and we will be back to square one. We are already seeing this happen, with only around 10% of the US population having opted to get the latest bivalent booster.
Human blood cells, SEM

Engineered Red Blood Cells Could Develop New COVID-19 Vaccines

Early results show engineered red blood cells can help create immunity against SARS-CoV-2 and treat COVID-19 by stimulating antibody production with minimal adverse effects.
Coronavirus particles, illustration - SARS-CoV-2 virus

Cancer Patients May Have Poor Responses to COVID-19 Vaccines

Researchers have found that patients with cancer who receive chemotherapy, and some targeted therapies including CDK4/6 inhibitors and therapies targeted at B cells, may mount an inadequate immune response to COVID-19 vaccination.
Young woman getting vaccinated

Dual Action COVID-19 Vaccines May Work for Longer

COVID-19 vaccines that also target another viral protein, the RNA polymerase that coronaviruses use to make copies of themselves, could help new vaccines offer longer-lasting protection, according to UCLA research.
Medical vaccine

Study Will Assess Reasons for Allergic Reactions to Moderna, Pfizer/BioNTech COVID-19 Vaccines

A new NIH-funded Phase II study will assess if people who are already highly allergic, or have a mast cell disorder, are at increased risk of an immediate systemic reaction after being given either the Moderna or Pfizer/BioNtech COVID-19 mRNA vaccines.
Developing mRNA Covid-19 Vaccines Concept

Will COVID-19 mRNA Advances Help Progress Cancer Vaccines To the Clinic?

Since the start of the pandemic, mRNA vaccine development to combat COVID-19 has happened extremely quickly, but can these scientific advances can have a positive impact on the development of cancer vaccines? The technology is definitely at a good point right now, but the choice of the right antigen or antigens to target seems key to getting cancer targeting mRNA vaccines to the clinic. At present the most developed of these vaccines are still at Phase II, so it remains to be seen which will be the first to succeed.
Doctor holding Coronavirus vaccine. COVID 19 concept

Some COVID-19 Vaccines More Effective Against New Strains Than Others

Recent results suggest that the Pfizer/BioNTech COVID-19 vaccine has good efficacy against the new UK and South African variants. But the AstraZeneca/Oxford University vaccine appears less effective against the South African variant, a trend emerging for several approved or near-approved vaccines.
Covid-19 vaccine circular pattern

AI Program Rapidly Designs Optimal COVID-19 Vaccines

The new machine-learning model, DeepVacPred, can accomplish vaccine design cycles that took months or years in minutes or seconds, according to its designers, researchers at the University of Southern California Viterbi School of Engineering. In their study, they used their model to design a multi-epitope vaccine against SARS-CoV-2.
The Lab

Merck Discontinues Development of 2 COVID-19 Vaccines

Merck acted after reviewing data from Phase I trials for its candidates V590 and V591. Both vaccines were generally well tolerated, but generated immune responses “inferior to those seen following natural infection and those reported for other SARS-CoV-2/COVID-19 vaccines,” the company said.

NIH to Launch Public-Private Effort to Accelerate Development of COVID-19 Vaccines, Treatments

The partnership will be coordinated by the FNIH, which will work with the government agencies and members of the pharmaceutical industry partners, to provide infrastructure, subject matter expertise and/or funding (both new and in-kind) as a means to advance the most promising vaccines and therapeutic candidates into clinical trials.

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