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Published on February 12, 2024
Genetic variation in the EPAS1 gene that influences our ability to store oxygen in the blood may be behind differences in symptoms and outcomes in people with diseases such as chronic obstructive pulmonary disease (COPD). Tatum Simonson, founder and co-director of the Center for Physiological Genomics of Low Oxygen at…
Published on September 28, 2023
A multi-center study of metabolic dysfunction-associated steatotic liver disease (MASLD) led by researchers at the University of Michigan has shown genetic variation that contributes to the development of the MASLD, and has identified seven distinct subgroups of the disease that suggest the need to take precision treatment approaches. MASLD, formerly…
Published on February 11, 2021
A new study from researchers at University of California, San Francisco (UCSF) has found that inherited genetic variation plays a role in who is likely to benefit from checkpoint inhibitors, which release the immune system’s brakes so it can attack cancer. The study also points to potential new targets that…
Published on January 29, 2021
A new study “A growth-factor-activated lysosomal K+ channel regulates Parkinson’s pathology” in Nature led by researchers from the University of Pennsylvania has revealed how two different variations—one that increases disease risk and leads to more severe disease in people who develop Parkinson’s and another that reduces risk—manifest in the body. The work, by…
Published on May 19, 2020
An analysis of data from over 100 studies including 266,000 women has unearthed 32 previously undiscovered areas in the genome where DNA variation appears to influence a women’s risk for developing breast cancer. The multinational research used information collected by the UK-based Breast Cancer Association Consortium over the last 15…
Published on March 25, 2020
Sponsored content brought to you by In cancer genomics, researchers are “really missing a lot of things by not looking for them in the right way,” says Shruti Iyer, a PhD candidate in the Genetics Program at Stony Brook University. In a recent talk in New York*, Iyer, who is…
Published on February 13, 2020
Radiation from cell phones is associated with higher rates of thyroid cancer among people with genetic variations in specific genes, according to researchers at the Yale School of Public Health and their collaborators. The group studied 176 genes in all and found 10 SNPs that appear to increase the risk…
Published on July 3, 2019
Researchers suggest that individual variation in genes alters our ability to regulate emotions, providing new insights that could help in the development of personalized therapies to tackle anxiety and depression. Some individuals are at greater risk of developing anxiety and depression than others and this depends in part upon the…
Published on June 12, 2019
A genome-wide association study GWAS, headed by a team at the University of Oxford, U.K., and involving thousands of children in the U.K. and the Netherlands, has linked a number of genetic variations with the level of protective antibodies generated following routine childhood immunizations. The scientists say that with further…
Published on January 21, 2019
Researchers say they have discovered 52 new genetic changes linked to osteoarthritis, which doubles the number of genetic regions associated with the disorder. A team from the Wellcome Sanger Institute, GlaxoSmithKline, and colleagues analyzed the genomes of over 77,000 people with osteoarthritis and reported their findings (“Identification of new therapeutic targets for osteoarthritis through…
Published on March 12, 2018
A study by scientists in the U.K., France, and the U.S. suggests that the degree of empathy we feel toward our fellow man is at least partly down to our genes. A genome-wide association study (GWAS) led by scientists at the University of Cambridge, U.K., found that about 10% of…
Published on December 12, 2017
Small differences in the genetic codes of individuals could significantly impact the efficacy, side effects and safety of treatments created via CRISPR/Cas9 gene editing according to researchers at Harvard Medical School, Boston Children’s Hospital, and the Université de Montréal. Their findings suggest that a one-size-fits-all approach to therapeutic gene editing…
Published on April 28, 2016
Researchers at the University of Chicago and Stanford University have described in a new study how thousands of RNA splice mutations affect gene regulation in traits such as height and diseases such as multiple sclerosis. The findings highlight the need for a better understanding of the role of RNA splicing…
Published on November 14, 2023
A genetic test that helps determine the best medication for patients with moderate-to-severe depression could generate substantive health system savings and greatly improve patient outcomes, according to new research from the University of British Columbia (UBC). The study, published in the Canadian Medical Association Journal (CMAJ), estimates that in British…
Published on October 18, 2023
Researchers from the Max Delbrück Center for Molecular Medicine and the Charité University Hospital in Berlin, Germany have uncovered the PDM16 gene as a previously unknown genetic factor that increases the risk of congenital heart failure in women. Heart failure, characterized by the heart’s inability to pump blood effectively, is…