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Researchers report that the Phase I IAVA G001 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine has exhibited a strong T-cell response in human subjects.

A mixed-race woman appears to have been cured of HIV after receiving stem cells from umbilical cord blood during the treatment of leukemia.

A new study reports the development of a unique native-like trimer (NLT) conformation of the HIV envelope that can generate neutralizing antibodies against difficult to neutralize HIV (tier-2) strains in mice.

A cluster of more than 100 individuals infected with the virulent subtype showed exceptionally high viral loads, rapid CD4 T cell decline, and increased infectivity, according to researchers at the University of Oxford.

Rhesus macaques receiving a priming vaccine followed by multiple booster inoculations had a 79% lower per-exposure risk of infection by simian-human immunodeficiency virus (SHIV) compared to unvaccinated animals.

To much of the world, the growing realization that vaccine-induced immunity for COVID-19 eventually fades has come as a shock. But for those of us who lived through the beginnings of the world’s last great pandemic, HIV/AIDS, the tremors feel oddly familiar. HIV and SARS-CoV-2 are two very different viruses, but they hold remarkable similarities.

The group will be led by researchers at Gladstone Institutes, Scripps Research Florida, and Weill Cornell Medicine. Their aim is to both silence and permanently remove HIV from the body, by leveraging knowledge about how other viruses have become naturally inactivated over time.

A blood biomarker signature discovered by researchers at the Wistar Institute predicts whether and when HIV patients will go into remission after stopping antiretroviral therapy.

The cell-attacks-host problem found in prior mouse models is due to so-called “naïve” CD4 cells. When the researchers excluded naïve CD4 cells and instead used only “memory” CD4 cells, the cells survived indefinitely in the mice without causing major damage to their hosts.

In vitro studies showed that the DNA origami particles, which mimic the size and shape of viruses, provoked a strong immune response from human immune cells.