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Published on August 22, 2024
A large study led by the Charité Medical University in Berlin shows no link between migraine and the risk of developing Parkinson’s disease in women aged 45 years and older. Writing in the journal Neurology, the investigators report that the risk of developing Parkinson’s disease over did not appear to…
Published on August 19, 2024
An implantable device that detects nerve signals to deliver personalized deep brain stimulation can improve the movement and sleep of people with Parkinson’s disease, a pilot trial has found. The findings, in four patients, are the first time that adaptive deep brain stimulation (aDBS) using “closed loop” brain implant technology…
Published on August 2, 2024
A large study of Parkinson’s disease genetics led by CENTOGENE, and the University of Rostock in Germany, shows approximately 15% of all cases of the disease are driven by genetic variants. As reported in the journal Brain, the researchers also confirmed that around 90% of individuals with a genetic form…
Published on July 31, 2024
Research led by Nagoya University Graduate School of Medicine shows higher than normal levels of neurofilament light chain protein can be detected in the blood of patients with presymptomatic, early-stage Parkinson’s disease and dementia with Lewy bodies. Writing in the journal npj Parkinson’s Disease, levels of tau and amyloid beta…
Published on July 29, 2024
A trial led by Helsinki University showed fecal microbiota transplants (FMTs) from healthy donors do not significantly improve symptoms of Parkinson’s disease in patients with the condition who had abnormal gut microbiome composition on enrollment. The transplants were safe and well tolerated, according to Filip Scheperjans, a neurologist and researcher…
Published on July 23, 2024
Research by Weill Cornell Medicine has led to the development of a new model for understanding Parkinson’s disease progression and offers an innovative method for early detection of the condition. The findings, published today in Nature Communications, could ultimately lead to better management strategies and improved outcomes for those affected…
Published on June 21, 2024
A vaccine for Parkinson’s disease could be on the horizon, according to a new study published in Nature Medicine. Vaxxinity’s immunotherapy targeting pathogenic α-synuclein aggregates has achieved its immunogenicity, safety, and tolerability goals in a phase I clinical trial in Parkinson’s patients. The vaccine, known as UB-312, was shown to…
Published on June 18, 2024
Research led by the University Medical Center Göttingen and the University College London (UCL) shows a test based on eight proteins found in the blood that can predict Parkinson’s disease up to seven years before any motor symptoms occur. As reported in Nature Communications, the researchers found that with the…
Published on June 13, 2024
Researchers from the University of Rochester Medical Center report in the journal npj Parkinson’s Disease that they have used a smartwatch paired with a mobile phone to detect and map disease progression in early Parkinson’s disease. Collecting these data via everyday consumer devices to develop a better understanding of disease progression…
Published on June 11, 2024
A potential landmark genetic association study for the neurodegenerative disorder Parkinson’s has uncovered a new risk variant. The team, which included scientists from the University Medical Center Utrecht, Indiana University School of Medicine, and UMass Chan Medical School, combined whole genome and exome sequencing data from 2184 familial Parkinson’s disease…
Published on May 14, 2024
Research led by the Icahn School of Medicine at Mount Sinai, New York, has confirmed a link between the genetics of inflammatory bowel disease (IBD) and Parkinson’s disease. The team that discovered the connection hopes their findings can help design therapies that could target both conditions. “Our research not only…
Published on April 15, 2024
A single fecal microbiota transplant (FMT) induced mild, but long-lasting beneficial effects on motor symptoms in patients with early-stage Parkinson’s disease (PD) in a small clinical study by Belgian researchers. About 20 people received the treatment, and their motor score improved by a mean of 5.8 points over a year. …
Published on March 21, 2024
Neurologists at Beth Israel Deaconess Medical Center (BIDMC) in Boston have developed a skin biopsy test able to assist in the early diagnosis of Parkinson’s disease and related neurodegenerative disorders, collectively known as synucleinopathies. The study, published in the Journal of the American Medical Association (JAMA), highlights the effectiveness of…
Published on February 8, 2024
A fluorescent coumarin-based, two-sensor array correctly discriminates between four different amyloids implicated in amyloid-related pathologies with 100 percent classification, according to research from an Australian team. Their work was published in ACS Sensors, and the lead author is Natalie Trinh of the University of Sydney. One of the biggest challenges…
Published on January 23, 2024
The Michael J. Fox Foundation will collaborate with omics-focused Centogene to research and confirm genetic and other omics-related risk factors for Parkinson’s disease. Centogene, which is headquartered in Germany, has a large biodatabank including samples from more than 800,000 people from more than 120 countries. This biobank includes data from…