An algorithm that can accelerate by years the ability to identify synergistic cancer drugs from among thousands of possibilities has been developed using single drug genomic and phenotypic data from public databases.
A droplet-based microfluidic technology produces micro-organospheres from cancer patient biopsies within an hour, using patient tumor, immune, and connective tissue cells.
The study indicates that the genetic program of T lymphocyte immune cells infiltrating malignant tumors, and the developmental path that these T cells then follow, may affect their response to immunotherapy.
A lineage tracing method based on CRISPR-Cas-9 inserts a sequence into a tumor’s genome to act as a digital barcode that can then be traced as tumor cells divide and change over time.
Initiating colorectal cancer screening earlier, at age 45 years rather than 50 years, substantially reduces the risk for colorectal cancer (CRC), including younger-onset disease, in women
The tool, known as CancerVar (Cancer Variants interpretation), incorporates machine learning frameworks to interpret the potential significance of those mutations in terms of cancer diagnosis, prognosis, and targetability.
Exposure to chemotherapy could increase risk for sperm damage and having children with genetic disorders in a small number of men.
54gene and its collaborators have published their strategic vision on the project to sequence the genomes of 100,000 Nigerians spanning 300 ethnic groups.
Researchers at Northwestern Medicine collaborated with the University of California, San Francisco, and the University of Hong Kong, and developed a drug that inhibits the growth of the most meningiomas in select patients, mouse models, organoids, and cell cultures.
Recombinant mouse immunoglobulin (mouse IgG) prevents human anti-mouse antibodies from binding to the capture or detection antibodies in an immunoassay. It is a novel and sustainable replacement blocking solution to serum-derived mouse IgG, providing manufacturers with a tightly controlled, non-animal derived antibody to efficiently reduce nonspecific interference in immunoassays.
