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Published on April 3, 2020
In one of the largest genetic studies of medulloblastoma, an analysis of more than 700 children and young adults with medulloblastoma revealed a major genetic difference in those with the Sonic Hedgehog subtype. The investigation was conducted by researchers from EMBL, KiTZ, the German Cancer Consortium, and St. Jude Children’s…
Published on July 25, 2019
Researchers using single-cell analysis have gained new insight into the most common type of childhood brain cancer. The team has pinpointed where in the brain one of the four subtypes of the cancer, called medulloblastoma, originates and further characterized another subtype. Their findings promise to impact clinical care for medulloblastoma.…
Published on January 19, 2023
Non-profit childhood cancer research and treatment organization CureSearch for Children’s Cancer announced on Wednesday that it will collaborate with leading research institutions and corporate sponsors to launch a health economics study on the benefits of providing molecular testing for children with cancer. According to CureSearch, the study is intended to…
Published on August 24, 2022
Almost half of children with high-risk neuroblastoma harbor extra copies of the gene MYCN (MYCN amplified), the primary driver of neuroblastoma and its resistance to therapy. However, no available therapies directly target MYCN. In a paper published in Nature Communications, researchers from Baylor College of Medicine delved into understanding metabolic vulnerabilities of…
Published on March 17, 2022
Genomic sequencing allowed 107 relapsed pediatric cancer patients to receive a matched targeted therapy that was not considered standard of care, according to recent data from an international clinical trial. The study was published in Cancer Discovery and the senior author was Birgit Geoerger, a professor of pediatric clinical research…
Published on February 9, 2022
Reliably predicting whether the most common primary brain tumor, meningioma, will recur or remain benign has not been easy. Now, a team of researchers from Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital report that molecular analysis of 365…
Published on August 25, 2021
Sponsored content brought to you by The brain tumor diagnostic conundrum Cancer is a leading cause of death worldwide, and brain tumors are the most common cause of cancer death in children. Luna Djirackor works at the Oslo University Hospital, Norway, where her team sees around 300 adults and…
Published on July 1, 2021
Sponsored Content From: The brain tumor diagnostic conundrum Cancer is a leading cause of death worldwide, and brain tumors are the most common cause of cancer death in children. Luna Djirackor works at the Oslo University Hospital, Norway, where her team sees around 300 adults and 30 children with brain…
Published on June 22, 2021
Scientists based at Icahn School of Medicine at Mount Sinai have discovered a new class of drugs that they think has potential to treat a subtype of non-Hodgkin’s lymphoma—mantle cell lymphoma—that is normally fatal. The drug candidates are small molecules that inhibit the action of the SOX11 oncogene and in…
Published on November 25, 2020
A comprehensive “proteogenomic” analysis has been completed of the proteins, genes, and RNA transcription in pediatric brain tumors, which are the leading cause of cancer-related deaths in children. The project was carried out by researchers from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and Children’s Brain Tumor Network (CBTN). It…
Published on February 6, 2020
Identifying the earliest mutational events for any cancer would be an invaluable step toward relevant treatment intervention. However, identifying exactly when genomic changes occur is no easy task. Yet now, investigators at EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analyzed the whole genomes of more than…
Published on January 9, 2020
If you dispatch a suicide gene, you want to make sure that it bypasses healthy cells on its way to harmful cells, such as cancer cells. What’s more, you want to make sure that the suicide gene is sent via a delivery system that treads lightly—especially if the suicide gene…
Published on November 21, 2019
New research published in The Cell from researchers at UC San Diego School of Medicine and Case Western Reserve School of Medicine shows non-coding DNA—often referred to as ‘junk’ DNA because it does not encode for any known function—can contribute to cancer development. The mechanism identified suggests that when an…
Published on November 12, 2018
About 20–30% of all cancers exhibit chromothripsis, a catastrophic genetic event in which sections of the chromosome effectively shatter into multiple pieces, but can’t reassemble correctly, resulting in missing, duplicated, or misaligned DNA sequences. Scientists at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) studying mouse models and human tumors now…
Published on May 4, 2016
The diagnostic work up of most malignant tumors is not complete unless the work up includes genomic characterization. At the time of diagnosis this may consist of a panel of prognostic and/or predictive analyses performed using cytogenetics, fluorescence in situ hybridization, standard molecular technologies, and next-generation sequencing (NGS). Whereas genomic…