21 Results
Sort By:
Published on June 15, 2022
Many biologists seek signals of gene expression and study the structure of tissues. Sequencing RNA (RNA-seq) reveals gene expression, and techniques evolved into single-cell RNA-seq (scRNA-seq), which uncovers the gene expression in just one cell. For spatial information about organisms, scientists use microscopy. To put together these two methods, scientists…
Published on March 3, 2022
A possible genetic cause of spontaneous coronary artery dissection (SCAD) has been identified by researchers at Massachusetts General Hospital (MGH). The mutations they linked to the condition are in genes that control the production of fibrillar collagen, the most abundant protein in the extracellular matrix or “scaffolding” that gives shape,…
Published on February 16, 2022
A set of genes underlying coronary artery disease (CAD) and triggering heart attacks has been identified in a major new study. Researchers uncovered 162 candidate CAD genes, which affect between one to seven disease-relevant tissues/cell types, including the arterial wall, blood, liver, skeletal muscle, adipose, foam cells, and macrophages. The…
Published on April 19, 2021
A team of European and Japanese scientists, led by Mariko Taniguchi-Ikeda, Ph.D., from Fujita Health University Hospital, have described a set of seven patients with a novel mitochondrial disorder caused by biallelic variants in ligase III (LIG3)—a ligase involved in DNA replication and repair. LG3 plays a role in mitochondrial…
Published on June 22, 2018
Clinical categories for psychiatric disorders may need to be rethought, suggests a new study from the aptly named Brainstorm Consortium, a collaborative effort that accepted input from researchers representing 600 institutions worldwide. By pooling their data on hundreds of thousands of genomes, these researchers found genetic connections among distinct psychiatric…
Published on February 22, 2017
A collaborative team of researchers led by scientists at the German Centre for Cardiovascular Research (DZHK) discovered that nearly half of all hereditary risk factors for coronary artery disease are also associated with entirely different diseases, such as schizophrenia, chronic inflammatory bowel disease, or migraines. This new study, published in…