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Published on January 19, 2022
Results from a large international study, performed as part of a competition called PANDA, show that artificial intelligence (AI) algorithms can accurately diagnose and grade prostate cancer. The researchers who set up the challenge had already produced AI algorithms to detect prostate cancer, but wanted to try and overcome the…
Published on January 12, 2022
Last week 23andMe announced the first participant has been dosed in a Phase I clinical trial evaluating its first wholly-owned drug candidate, 23ME-00610, for the treatment of advanced solid tumors. The company also received FDA clearance this week for its new test to detect a hereditary marker of prostate cancer.…
Published on December 30, 2021
Black men with more aggressive disease appeared to have better outcomes than their white counterparts in a meta-analysis of radiation therapy trials, according to a study by UCLA Jonsson Comprehensive Cancer Center researchers. “These results provide high-level evidence challenging the common belief that Black men who are diagnosed with prostate…
Published on December 13, 2021
Researchers at UCLA Jonsson Comprehensive Cancer Center led a large international study providing what may be the first evidence that a recently approved imaging technique, PSMA PET/CT, improves risk stratification and long-term prognostic estimation for patients with high-risk prostate cancer whose conventional imaging showed only localized disease. “Our findings also…
Published on November 10, 2021
Researchers at Barts Cancer Institute, Queen Mary University of London have developed a testing regimen using circulating tumor cells (CTCs) found in a patient’s blood that can identify resistance to the common cancer treatment docetaxel for prostate cancer. The findings, presented at the NCRI Festival, could pave the way for…
Published on October 28, 2021
Researchers at the Cleveland Clinic have demonstrated, for the first time, an association between diet-associated molecules found in the gut with aggressive prostate cancer. The results, published today in the journal Cancer Epidemiology Biomarkers & Prevention, suggest that dietary interventions may help reduce the risk of this aggressive form of…
Published on October 26, 2021
A new meta-analysis finds that a genetic biomarker test accurately predicts how men with high-risk prostate cancer respond to treatment with radiation and hormone therapy. The study, which examined biopsy samples collected from three large, randomized clinical trials, indicates that physicians potentially can use genetic test scores to personalize treatment…
Published on October 8, 2021
A research collaboration between British and Swiss scientists has shown in a preclinical study how bacteria in the gut can contribute to both the progression of advanced prostate cancer and developing resistance to hormone therapy. The findings are published in the journal Science in a paper titled, “Commensal bacteria promote endocrine resistance…
Published on August 30, 2021
Research led by the University of California, Irvine shows RNA expression differences between prostate tumor and nearby tissue samples that could help explain why Black Americans are more severely affected by this type of cancer than White Americans. Black Americans are diagnosed with prostate cancer earlier and at a more…
Published on August 16, 2021
Weeks after reporting results from their research demonstrating that magnetic resonance imaging (MRI) could reduce overdiagnosis and thereby improve prostate cancer screening, investigators at the Karolinska Institute in Sweden published a new study showing that the addition of a novel blood test, the Stockholm3 test, can reduce the number of…
Published on August 3, 2021
A team at the University of Michigan Rogel Cancer Center has discovered that targeting the lipid kinase PIKfyve may be an effective treatment strategy alone—or in combination with immunotherapies—against the most challenging type of prostate cancer. The study is published in Nature Cancer in the paper, “Autophagy inhibition by targeting PIKfyve potentiates…
Published on June 21, 2021
New mechanisms underlying a type of prostate drug resistance called lineage plasticity have been uncovered. This type of resistance emerges when cells in castration-resistant prostate cancers shift from a glandular to a neuroendocrine type, which can behave more like small cell lung cancer. he new research finds that E2F1 and…
Published on February 25, 2021
Researchers at the University of California (UC) San Diego School of Medicine, who led an international team of investigators, announced the validation of a more inclusive and comprehensive genetic tool for predicting age of onset of aggressive prostate cancer, a disease that killed more than 33,000 American men in 2020.…
Published on January 5, 2021
It’s an open secret that the lack of racial and ethnic diversity of genetic studies, has created care disparities in the practice of precision medicine. It is especially troubling in diseases such as prostate cancer where it is well known that some racial and ethnic groups fare worse than others…
Published on November 11, 2020
A genetic signature made up of 16 gene variants can predict if men with prostate cancer will respond to therapy and how likely their cancer is to spread. The researchers, based at Columbia University Irving Medical Center in New York, hope that testing men with prostate cancer for this signature…