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Groundbreaking Study IDs Brains Signatures, Biomarkers of Chronic Pain
Research from a National Institutes of Health-funded study that collected pain-related data from within the brains of small cohort of patients has identified a specific area of the brain and related biomarkers associated with chronic pain.
Chronic Pain is Experienced Differently by Men and Women
A collaborative Canadian study has discovered sex-specific mechanisms of chronic pain processing in neurons of the spinal cord that are conserved across species from rodents to humans, a finding which could lead to the development of more personalized therapies for this indication in the future.
Researchers Find Three Genetic Variants Linked to Chronic Back Pain
The genome-wide association study analyzed samples of 158,000 individuals of European ancestry including 29,000 with chronic back pain
Gene Mutation Identified That Helps Regulate Pain
Researchers have discovered a potential pain insensitivity mutation that codes for a protein known to mitigate the sensory response to heat and the burning sensation caused by chili peppers.
Lilly and Confo Ink Deal around Non-Opioid Pain Candidate
Confo Therapeutics, which specializes in targeting G-protein coupled receptors (GPCRs), has announced a worldwide licensing agreement with Eli Lilly a non-opioid pain medication.
Use of Common Painkillers Linked to Heart Failure in Type 2 Diabetes Patients
Ibuprofen and diclofenac may increase the risk of heart failure in patients with type 2 diabetes according to Danish research.
Aiming Precision Medicine at Chronic Diseases
Digging deeper into biology could produce targeted drugs and diagnostics to treat a collection of life-long conditions.
Comprehensive Genomic Profiling (CGP) has the promise to be a game-changer to inform precision oncology, but the hurdles remain.
Mesoblast’s Cell Therapy Proves Effective for Lower Back Pain
Late stage results for Mesoblast's rexlemestrocel-L allogenic cell therapy look promising for patients with lower back pain due to degenerative disc disease.
Cancer Drug Screening Method Finds One That May Be an Effective Pain Medication
Studies indicated that kenpaullone acts by boosting levels of an ion transporter gene that is involved in maintaining inhibitory GABA-ergic neurotransmission, with tests in rodent models of nerve injury and bone cancer confirming that the drug effectively reduced pathologic pain-like behavior.