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Published on April 23, 2024
A research team in Spain, reporting in the Journal of the American College of Cardiology, say they have identified five subtypes of dilated cardiomyopathy (DCM), and created the first risk stratification of disease development among symptom-free people who carry a genetic mutation that can cause it. Estimates suggest that in…
Published on January 25, 2024
Researchers at the Mayo Clinic investigating factors related to recovery from dilated cardiomyopathy have identified a variant in a specific gene that plays a role in people who recover from the condition and those who don’t. Results of the genome-wide association study (GWAS), published in Circulation Research, is expected to…
Published on February 2, 2022
A research study, led by the Ohio State University Wexner Medical Center, reveals the genetic nature of many cases of the heart muscle disorder dilated cardiomyopathy (DCM) and shows that Black families seem to have higher rates of inherited DCM than families of other ethnicities. Writing in JAMA, the research…
Published on February 1, 2021
Scientists from the University of Pennsylvania have discovered how mutations in the LMNA gene cause a congenital form of dilated cardiomyopathy, a serious heart condition that can be fatal. The researchers found that LMNA gene mutations have a particularly adverse effect on cardiac muscle cells compared to other cell types,…
Published on August 16, 2019
Renovacor, a preclinical-stage gene therapy company, has announced the successful completion of an $11 million Series A financing co-led by Novartis Venture Fund, Broadview Ventures, and BioAdvance, which were joined by New Leaf Venture Partners and Innogest Capital. Proceeds from the financing will help advance the company’s first-of-its-kind gene replacement…
Published on April 24, 2024
Heart disease in women is underdiagnosed compared to men. Now, more accurate cardiovascular risk models for women have been developed by U.S. and Netherlands researchers using a dataset of more than 20,000 participants in the UK Biobank. This team also quantified the underdiagnosis of heart disease in women. They say…
Published on June 6, 2023
An analysis from the BabySeq Project, which trialed newborn sequencing in apparently healthy and unwell babies, found 17 infants with potentially pathogenic monogenic genetic findings that were all moderately or highly actionable. Of these infants, two-thirds were referred to specialist consultation, treatment or surveillance and all their at-risk first-degree relatives…
Published on February 10, 2023
The Genotype and Phenotype Database of Monogenic Cardiovascular Disease, or CardioGen, has been established by China’s BGI Genomics, together with the National Center for Cardiovascular Diseases, Fuwai Hospital, and the State Key Laboratory of Cardiovascular Diseases. CardioGen collects and integrates information about gene-causing diseases and clinical phenotype information of patients found in…
Published on August 5, 2022
A study published in the journal Science has challenged the idea that heart failure results from a common disease pathway, suggesting instead that individual genetics comes into play. The research revealed that genetic variants activate specific pathways in cardiomyopathies, some shared and some distinct, that resulted in different cellular landscapes…
Published on July 28, 2021
A protein that helps regulate calcium signaling within heart cells could play a key role in preventing chronic heart failure, and could therefore be a good target for drug development, according to an international study led by University of Utah Health scientists. Voltage dependent anion channel 2 (VDAC2) is an…
Published on July 15, 2020
SARS-CoV-2 causes infection primarily by binding to the human angiotensin-converting enzyme 2 (ACE2) receptor in the upper respiratory epithelium and lungs. However, nearly 20% of all COVID-19-associated deaths are from cardiac complications. There is much debate about how such complications arise, how to treat them, and whether patients already taking…
Published on August 10, 2018
Researchers at the University of Alabama at Birmingham have described an underlying mechanism that reprograms the hearts of patients with ischemic cardiomyopathy, a process that differs from patients with other forms of heart failure, collectively known as dilated (non-ischemic) cardiomyopathies. This points the way toward future personalized care for ischemic…
Published on April 16, 2018
When President Obama announced the Precision Medicine Initiative at the State of the Union in 2015, it recognized more than a decade of work that scientists and medical researchers had already committed to identifying the underlying genetic causes of diseases and specific pathways to treatment. To date, there have been…