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NK Cell (Natural Killer Cell) Attacking a Cancer Cell

Cancer Immunotherapy Expansion Using a New Predictive Biomarker

In this Inside Precision Medicine webinar, our distinguished guest speaker, Dr. Scott Tomlins, will describe the development, validation, and clinical utility of a new pan-tumor predictive biomarker for immunotherapy benefit: Immunotherapy Response Score (IRS).
T-Cells Attacking Cancer Cell

Blocking T-Cell Migration with Immunotherapy Slows Melanoma Growth

Using a chemical blocker stops CD8+ T cells from migrating out of skin cancer cells. Together with immunotherapy, this new approach could boost the efficacy of immunotherapy.
3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

Immunotherapy Response Affected by CD5+ Cells

CD5+ cells could be an important marker for response to immunotherapy for melanoma and other cancers, according to new research from the Washington University School of Medicine. 
Lung cancer, illustration

New Insights to Poor Lung Cancer Response to Immunotherapy

Bacteria naturally found in the lungs help create an environment that suppresses T-cell activation in the lymph nodes near the lungs—a finding that could explain why immunotherapy for lung cancer often fails.
Tumor microenvironment

Persistent Mutations in Tumors May Predict Response to Immunotherapy

New evidence from researchers at the Johns Hopkins Kimmel Cancer Center has found that a subset of mutations within the TMB—defined at “persistent mutations"—are less likely than others to be edited out, making them always visible to the immune system which results in them being more likely to respond to immunotherapies.
3d illustration of a cross-section of a diseased skin with melanoma that enters the bloodstream and lymphatic tract

Melanoma Immunotherapy Boosted by Sugar Found in Seaweed

L-fucose, a nontoxic dietary plant sugar that is enriched in red and brown seaweeds, can increase TILs, promote antitumor immunity, and improve the efficacy of immunotherapy.
Colorectal polyps, illustration

Pre-Surgery Immunotherapy for Colorectal Cancer Proves Highly Effective

Using immune checkpoint inhibitors prior to surgery of patients with localized mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC) is an effective approach to treating the disease
T-Cells Attacking Cancer Cell

Gilead to Purchase Remaining Rights to Potential First-in-Class Immunotherapy from Jounce Therapeutics

Gilead Sciences and Jounce Therapeutics announced late Tuesday amendments to the existing terms and licensing agreements for GS-1811 (previously called JTX-1811), a potential first-in-class anti-CCR8 antibody in development as a potential treatment against solid tumors.
Inmunologically active proteins on a T-cell: T-cell receptor, CD-4, CD-28, PD-1 and CTLA-4 and a calcium channel

Reducing Hypoxia May Improve Immunotherapy

Tired T cells not only lose their own ability to fight cancer; they also influence surrounding cells to suppress an immune response.
Microscope photo of a human large intestine section with inflammation

Qu Biologics Taps Karolinska Institute to Validate Qu’s Immunotherapy Platform

The research will be led by Prof. Jonas Fuxe, and will characterize the molecular targets of Qu's Site Specific Immunomodulator (SSI) therapy at the tissue level that lead to resolution of disease.


Inside Precision Medicine