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Published on April 2, 2024
Unique proteomic signatures could provide more accurate diagnosis and prognosis of sepsis, according to work from researchers at the Lund University. These markers could also help to target specific therapies for patients. Their study is being presented at this year’s European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024)…
Published on September 27, 2023
Independent research led by Pennsylvania State University shows Cytovale’s IntelliSep sepsis test is less costly and slightly more accurate than testing for procalcitonin, a widely available biomarker diagnostic for sepsis. The researchers predicted that more than 95% of patients with sepsis would survive at a cost of less than $4000…
Published on February 1, 2023
Patients treated for sepsis during hospital stays were at much greater risk of cardiovascular events and rehospitalization for any cause, or death, for as long as 12 years after, according to a study published today in the Journal of the American Heart Association. The study looked at claims data for approximately 2.3…
Published on October 24, 2022
Metagenomic RNA and DNA next generation sequencing can pinpoint sepsis patients from those with non-infectious systemic inflammatory conditions. From whole-blood gene expression data, patients with sepsis were distinguished from those with non-infectious systemic inflammatory conditions using a trained bagged support vector machine (bSVM) classifier. Pathogen detection of plasma mNGS varied…
Published on July 25, 2022
An adaptive artificial intelligence (AI) technology called the Targeted Real-time Early Warning System (TREWS) developed by Bayesian Health has shown its ability in a clinical setting to be an effective early warning screening tool for patients with sepsis. Detailed in three separate studies published in Nature and npj Digital Medicine,…
Published on February 12, 2021
A specialized biosensor allows quick and accurate detection of multiple sepsis biomarkers – procalcitonin, C-reactive protein and pathogen-associated molecular patterns — from a blood sample. The sensor was developed as a collaboration between Harvard’s Wyss Institute for Biologically Inspired Engineering and the University of Bath in the UK. It combines…
Published on May 13, 2020
Disease architecture of the sepsis cohort generated by the PrecisionLife platform. Each circle represents a disease associated SNP genotype, edges represent co-association in patients, and colors represent distinct patient sub-populations or ‘communities’. [PrecisionLife]PrecisionLife said its data scientists have identified 59 drug candidates suitable for repurposing into…
Published on July 15, 2019
Syndromic test developer iCubate has won FDA clearance for its ic-GN Assay, a qualitative, multiplexed, in vitro diagnostic test designed to detect and identify potentially pathogenic gram negative bacteria associated with bloodstream infection (BSI) and subsequent sepsis. The iC-GN Assay has been developed to detecs target DNA, and identify gram…
Published on February 22, 2017
The FDA granted 510(k) clearance to Immunexpress for the use of its SeptiCyte™ LAB as an aid in differentiating infection-positive (sepsis) from infection-negative (SIRS) systemic inflammation in critically ill patients on their first day of ICU admission. SeptiCyte LAB is the first RNA-based clinical diagnostic tool, direct from whole blood,…
Published on February 1, 2016
Because sepsis is characterized by nonspecific symptoms and can progress quickly—with fatal results—biomarkers that can characterize the condition are dearly needed. Ultimately, multiple biomarkers may serve to characterize different aspects of the disease. With an eye toward this multibiomarker possibility, researchers at Lund University and the University of Zurich have…
Published on April 3, 2024
SAN DIEGO—Eric Topol, MD, renowned cardiologist and Director of the Scripps Research Translational Institute, believes that the use of artificial intelligence (AI) will be “the biggest transformation in the history of medicine.” As a keynote speaker at the 31st annual Precision Med TRI-CON meeting, hosted by Cambridge Healthtech Institute, Topol…
Published on January 3, 2024
A new antibiotic class that works against multidrug-resistant bacteria has been discovered, offering new opportunities to tackle these dangerous microbes. The macrocyclic peptide zosurabalpin showed promising antibacterial activity against Carbapenem-resistant Acinetobacter baumannii (CRAB), according to two papers published in the journal Nature. The Gram-negative bacteria is deemed an urgent threat by the U.S.…
Published on December 27, 2023
Researchers have discovered two common genetic variants that offer protection against pericarditis, paving the way towards more targeted and personalized treatments. The dual discovery at a gene locus for interleukin (IL)-1 cytokines could help tailor therapy with a group of drugs that block the action of these proteins, which recently…
Published on July 17, 2023
A novel research study led by investigators from the Johns Hopkins Armstrong Institute Center for Diagnostic Excellence estimates that 795,000 Americans die or are permanently disabled each year due to diagnostic errors. The new findings point to the pressing need to reduce diagnostic errors and confirm the U.S. National Academy…
Published on May 4, 2023
Bacterial bloodstream infections in extremely preterm babies may originate from their gut microbiomes, research suggests. Identical or nearly identical gut bacteria were found in more than half of the cases before a bloodstream infection was diagnosed, according to the study in Science Translational Medicine. Numerous babies in the same neonatal…