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Published on September 26, 2023
New research led by investigators at Uppsala University in Sweden shows emerging evidence that autologous hematopoietic stem cell transplantation (aHSCT) may be a suitable treatment for relapsing-remitting multiple sclerosis (MS). Relapsing-remitting MS (RRMS) is characterized by distinct inflammatory episodes that result in varying degrees of disability. The symptoms will resolve…
Published on August 3, 2023
New findings from a study lead by researchers from the University of California, Los Angeles (UCLA) have described a pathway that protects the liver from injury during transplantation. The protein, called CEACAM1, helps protect the organ when blood supply is returned to the organ during transplantation reducing inflammation and tissue…
Published on May 5, 2023
A machine-learning algorithm could offer personalized predictions of life expectancy following lung transplantation, research suggests. The random survival forests (RSF) model had “excellent performance” in predicting both survival overall and at the specific time points of one month and a year, revealed the researchers. It was significantly better than a…
Published on January 18, 2022
A team of researchers has discovered a technique to make immunomodulation after pancreatic islet transplantation more effective using nanocarriers to re-engineer the commonly used immunosuppressant rapamycin. Islet transplantation has emerged over the past few decades as a potential cure for type 1 diabetes. However, transplantation efforts have faced setbacks, as…
Published on February 5, 2019
SQI Diagnostics will partner with University Health Network (UHN) to create and license rapid multiplexed protein assays and a point-of-care (POC) diagnostic device designed to help transplant surgeons assess the suitability of lungs and other organs for transplantation, through a collaboration whose value was not disclosed. SQI said it will…
Published on May 20, 2024
Gwen Chambers has had a lot to contend with as a patient—she’s beaten cancer twice, including stage IV Hodgkin’s lymphoma, and then twenty years later was diagnosed with heart failure and received a transplant. But nothing has been more dreadful and uncomfortable than the post-transplant heart biopsies checking for graft…
Published on April 29, 2024
The human gut bacteria Akkermansia muciniphila produces enzymes that are able to remove ABO blood group related antigens on the surface of red blood cells, which could help provide blood for those who need it in the absence of suitable donors. In a paper published in Nature Microbiology, the researchers…
Published on April 23, 2024
A research team in Spain, reporting in the Journal of the American College of Cardiology, say they have identified five subtypes of dilated cardiomyopathy (DCM), and created the first risk stratification of disease development among symptom-free people who carry a genetic mutation that can cause it. Estimates suggest that in…
Published on April 12, 2024
Research led by the University of Chicago shows an artificial intelligence (AI) driven “digital twin” modeling the infant microbiome can predict neurodevelopmental problems later in infancy. Using data on very early gut microbiome composition from fecal samples from preterm babies the digital twin predicted later microbiome composition and associated neurodevelopmental…
Published on March 29, 2024
Researchers have called for people donating tissue, organs, stem cells and blood to undergo genomic sequencing, following preclinical studies showing that Alzheimer’s disease can be transferred in bone marrow. The team discovered an unexpected, transferable form of the neurodegenerative disease, which mice undergoing bone marrow transplantation developed at an accelerated…
Published on March 14, 2024
Researchers have developed a model to evaluate gene therapy using a whole human liver, which could help create novel viral vectors for next-generation treatments. The development of the human liver ex situ normothermic perfusion model broadens the repertoire of preclinical models available to assess tools for delivering gene therapies. It…
Published on March 5, 2024
Novo Nordisk today announced it has notched another win for its GLP-1 agonist semaglutide (Ozempic), this time for reducing cardiovascular disease and slowing kidney disease in diabetic patients. The latest results from the FLOW trial suggest the drug cuts risk of death in this population by as much as 24%. …
Published on February 16, 2024
Researchers have created a new scoring system that could create fairer access to organ transplantation. The continuous, multivariable prediction model was better than existing U.S. criteria at ranking adult heart transplant candidates according to medical urgency. The current system uses subjective physician decisions and has been criticized as being open…
Published on February 8, 2024
Researchers have used a gene editing technique to treat a rare immune disorder that could help overcome concerns over the use of gene therapy in these patients. The treatment targets deficiencies in recombination activating genes (RAGs), which can affect the production of lymphocytes and cause severe immune disorders. Specifically, it…
Published on January 19, 2024
In a crucial Phase I/II trial, researchers at The University of Texas MD Anderson Cancer Center have reported significant success in treating patients with relapsed or refractory B-cell malignancies using cord blood-derived chimeric antigen receptor (CAR) natural killer (NK) cell therapy targeting CD19. The findings, published in Nature Medicine, show…