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Early stage cervical cancer rates fell, while cases of advanced disease have increased, in the US every year for the last couple of decades.

Men’s greater susceptibility to cancer may be due to underlying biological sex differences rather than behavioral factors.

GSK’s immunotherapy Jemperli (dostarlimab) had a 100% complete response in a small trial for mismatch repair-deficient (MMRd) rectal cancer.

The study shows that the group of boys overweight at age 8 had an increased risk of obesity-related cancer in adulthood. This applied particularly to those whose weight remained elevated at age 20.

Precision therapy developer Foghorn Therapeutics will deploy its Gene Traffic Control platform to regulate chromatin in collaboration with Loxo Oncology at Lilly

Molecular and tumor profiles of people with cancer aged 50 or younger show significant differences compared to older individuals with the same cancer, suggesting age should be taken into account when considering treatment options.

High tumor mutation burden is only predictive of good response to immune checkpoint therapy in cancers with a positive correlation between the production of neoantigens and CD8 T-cell production by the immune system, according to research from the University of Texas MD Anderson Cancer Center.

The scientists at the University of Turku Bioscience Center observed that the Sortilin-related receptor (SorLA) functionally contributes to the most reported therapy-resistant mechanism by which the cell-surface receptor HER3 counteracts HER2 targeting therapy in HER2-positive cancers.

The researchers introduced machine learning algorithms that use protein interaction networks that can interact with target proteins as well as the transcriptome of individual proteins that are directly related with drug targets.

Standard guidelines to determine which patients with cancer should undergo genetic testing only identified 48% of the patients with an inherited genetic mutation.