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Organoids Could Guide Personalized Therapy for Head and Neck Cancers
Researchers have developed a biobank of over 100 organoids that could help personalize head and neck cancer treatment.
Tumor Organoids May Help Treatment Selection for Biliary Tract Cancer
Patient-derived tumor organoids--3D tissue cultures derived from tumor tissue samples--could be used to predict the most suitable treatment for patients with biliary tract cancer, suggests research presented at Digestive Disease Week 2023 in Chicago.
Organoids Provide Insights into Rare Liver Cancer
Organoids and CRISPR-Cas9 have allowed researchers to better understand the tumor biology and biological consequences of different DNA changes of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer.
Brain-Like Organoids for Autism Research Created by University of Utah Scientists
The seed-sized brain-like organoids are reminiscent of one wrinkle in the human brain 15 to 19 weeks post-conception.
Organoids for Airway and Alveolar Disease Modeling
In this Learning Lab, sponsored pHcbi, we discussed the development of respiratory airway and alveolar organoids derived from human iPSCs and how these are used in modeling respiratory diseases such as cystic fibrosis.
Novel Organoid Shows Kidney Tumors in TSC Follow Multiple Paths
Custom-made kidney organoids have pointed to which cells, and pathways, cause tumors in patients with tuberous sclerosis complex (TSC).
Gene Therapy Helps Reverse Autism-Associated Mutation in Brain Organoids
University of California, San Diego (UCSD), School of Medicine scientists used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. The scientists used gene therapy tools to recover the gene’s function.
Researchers Create Organoids that Model BRCA-Positive Ovarian Cancer
The fallopian tube-based organoids may help predict which individuals with BRCA-1 mutations will develop ovarian cancer years or even decades in advance, and could be used to develop personalized therapies.
Tumor Organoids Could Help Guide Immunotherapy for Appendiceal Cancer
Immunotherapies tested on the organoids can potentially support treatment decisions and can achieve personalized results by identifying beneficial treatments while sparing patients from the harmful side effects of drugs from which they will obtain no benefit.
Intestinal Organoids Developed to Test New Drugs for COVID-19
SARS-CoV-2 affects many parts of the body. Although the primary manifestations of COVID-19 involve the respiratory system, gastrointestinal effects may play a critical role in both disease severity and transmission.
