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Illustration of a human head and neck showing a cut-through to the brain on the left hand side on a background picture of fluorescent neurons and with a DNA helix to the right hand side to represent genetic brain and neurological disorders such as the movement disorder ataxia.

Organoids Could Guide Personalized Therapy for Head and Neck Cancers

Researchers have developed a biobank of over 100 organoids that could help personalize head and neck cancer treatment.
Close up of a cancer cell - 3d illustration

Tumor Organoids May Help Treatment Selection for Biliary Tract Cancer

Patient-derived tumor organoids--3D tissue cultures derived from tumor tissue samples--could be used to predict the most suitable treatment for patients with biliary tract cancer, suggests research presented at Digestive Disease Week 2023 in Chicago.
Liver cancer, illustration

Organoids Provide Insights into Rare Liver Cancer

Organoids and CRISPR-Cas9 have allowed researchers to better understand the tumor biology and biological consequences of different DNA changes of fibrolamellar carcinoma (FLC), a rare type of childhood liver cancer.
Brain Organoids Provide Window inot Autism

Brain-Like Organoids for Autism Research Created by University of Utah Scientists

The seed-sized brain-like organoids are reminiscent of one wrinkle in the human brain 15 to 19 weeks post-conception.

Organoids for Airway and Alveolar Disease Modeling

In this Learning Lab, sponsored pHcbi, we discussed the development of respiratory airway and alveolar organoids derived from human iPSCs and how these are used in modeling respiratory diseases such as cystic fibrosis.

Novel Organoid Shows Kidney Tumors in TSC Follow Multiple Paths

Custom-made kidney organoids have pointed to which cells, and pathways, cause tumors in patients with tuberous sclerosis complex (TSC).
Autism spectrum disorder, conceptual illustration

Gene Therapy Helps Reverse Autism-Associated Mutation in Brain Organoids

University of California, San Diego (UCSD), School of Medicine scientists used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development. The scientists used gene therapy tools to recover the gene’s function.
Illustration of female reproductive system including uterus and ovaries to represent ovarian cancer

Researchers Create Organoids that Model BRCA-Positive Ovarian Cancer

The fallopian tube-based organoids may help predict which individuals with BRCA-1 mutations will develop ovarian cancer years or even decades in advance, and could be used to develop personalized therapies.

Tumor Organoids Could Help Guide Immunotherapy for Appendiceal Cancer

Immunotherapies tested on the organoids can potentially support treatment decisions and can achieve personalized results by identifying beneficial treatments while sparing patients from the harmful side effects of drugs from which they will obtain no benefit. 
Coronavirus, virus, flu, bacteria close-up. Abstract 3D rendered illustration

Intestinal Organoids Developed to Test New Drugs for COVID-19

SARS-CoV-2 affects many parts of the body. Although the primary manifestations of COVID-19 involve the respiratory system, gastrointestinal effects may play a critical role in both disease severity and transmission.


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