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Syndax’s revumenib shows promise in advanced acute leukemias with KMT2A rearrangements or mutant NPM1, according to findings published this week in Nature.

Children with acute lymphoblastic leukemia (ALL) who lived along the Texas border with Mexico were more likely to die within five years than those living in other areas of the state.

A study by researchers at St. Jude Children’s Research Hospital delving into drug response across a swath of genetic subtypes of acute lymphoblastic leukemia (ALL), could provide a map for clinicians to more precisely match available treatments with a patient’s specific form of cancer.

A key inhibiting molecule called DUSP6, plays an important role in overcoming the resistance secondary acute myeloid leukemia often develops in response to treatment with drugs called JAK2 inhibitors.

A mathematical model may predict those patients with the blood cancer chronic myeloid leukemia who will best respond to treatment with tyrosine kinase inhibitors.

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By rewiring the inner workings of the cancer cells and inhibiting a certain enzyme, researchers were able to prime acute myeloid leukemia (AML) cells for sensitivity to treatment in the laboratory and help reverse the resistance of leukemia cells to tyrosine kinase inhibitors (TKI).

Researchers have created a new vaccine against SARS-CoV-2—CoVac-1—that induces a T cell immune response in a high proportion of patients with leukemia and lymphoma.

Malformed early lymphocyte precursor cells are common in treatment-resistant infant B-cell acute lymphoblastic leukemia and have distinct biological markers that could be targeted in future treatments, shows U.K. research.

To help overcome relapse of T-cell acute lymphoblastic leukemia (T-ALL), researchers from Princess Máxima Center for pediatric oncology in Utrecht, the Netherlands, collaborated with Amsterdam UMC to find new ways to tackle the disease. The researchers demonstrated in mice that blocking a protein chain reaction makes childhood leukemia cells more sensitive to an existing targeted treatment.