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Published on September 8, 2020
A team of researchers led by investigators at the University of California, San Diego (UCSD), have identified a collective signature of proteins and metabolites that lab tests indicate can predict with exceptional accuracy the likelihood of death resulting from bacteremia (SaB)—a bacterial infection in the blood that kills 20–30% of…
Published on April 24, 2023
Research from a five-year study conducted by investigators at NYU Grossman School of Medicine and Janssen Biotech has demonstrated, in early tests, that a bioengineered drug candidate has shown superior performance treating Staphylococcus aureus compared with standard antibiotic treatment, including the treatment-resistant form MRSA (methicillin resistant Staphylococcus aureus). In a…
Published on April 12, 2023
New findings suggest Staphylococcus aureus bacteria has evolved to grow faster on the skin of people with the chronic skin condition atopic dermatitis, also known as eczema. While S. aureus bacteria is mostly harmless in people with healthy skin, the inflammation and cracks in the skin of people with eczema…
Published on June 11, 2021
Researchers from New York University School of Medicine have discovered that inhibiting hydrogen sulfide production in some bacteria—such as Staphylococcus aureus and Pseudomonas aeruginosa—could make them more susceptible to antibiotics. Some bacteria have developed strategies to tolerate and survive exposure to antibiotics, a process somewhat different to antibacterial resistance, which…
Published on May 10, 2021
A research collaboration led by Ben Gurion University has developed molecular tweezers to combat antibiotic resistant bacteria by breaking up biofilm formation. ‘Molecular tweezers’ are molecules designed with open gaps that can bind to other molecules in a tweezer-like fashion. They are still a relatively new concept, but have potential…
Published on August 8, 2017
Researchers at the Milner Center for Evolution at the University of Bath in the U.K. have demonstrated that sequencing the DNA of Methicillin-resistant Staphylococcus aureus (MRSA) can help identify patients most at risk of death from MRSA and could provide the basis for the development of new therapies to combat…
Published on April 24, 2024
A team of researchers led by Michigan State University (MSU) in collaboration with Harvard Medical School and the National Cancer Institute has developed a promising vaccine candidate to fight antibiotic-resistant bacteria. Using a novel vaccine delivery platform, researchers in the lab of Xuefei Huang, PhD, a professor of chemistry and…
Published on February 16, 2024
A collaboration between researchers at the University of Illinois Chicago (UIC) and Harvard University has resulted in the development of a new, promising antibiotic that effectively suppresses pathogenic bacteria that have become treatment-resistant. Details of the new antibiotic are published in the journal Science. The novel antibiotic is the latest…
Published on November 20, 2023
Research led by Washington State University shows a new 3D printed material could help reduce infections linked to medical implants such as knee and hip joint replacements in the future. As reported in the International Journal of Extreme Manufacturing, the researchers added a small amount of a corrosion-resistant metal called…
Published on November 9, 2023
A single, master genetic regulator can improve the effectiveness of T cells in cancer therapy and could extend their use for other diseases, researchers have discovered. A member of the BAF chromatin remodeling complex was able to reprogram T-cell genes to improve their cancer-killing abilities and reduce the chances of…
Published on May 25, 2023
North-American researchers have used machine learning to discover a new compound that controls bacterial infection, highlighting the value of artificial intelligence in antibiotic discovery. Screening around 7500 molecules revealed that the antibacterial compound abaucin, which was originally touted as an anti-diabetes drug, could inhibit the growth of Acinetobacter baumannii in vitro.…
Published on September 27, 2022
U.S researchers have developed a rapid processing system that can dramatically improve the time taken to detect bacterial and fungal infections in the bloodstream, potentially allowing faster administration of antibiotics. The culture-free, “biphasic” approach enables pathogen DNA to be amplified directly from just 1 ml of whole blood, reducing the…
Published on July 8, 2022
U.S. researchers have discovered why potential vaccines against Staphylococcus aureus have failed in clinical trials despite showing promise in laboratory studies. The team reports in Cell Host and Microbe that prior exposure to the bacterium appeared to be key in determining whether vaccine candidates could work. Specifically, prior staph exposure seemed…
Published on May 4, 2021
Researchers at Case Western Reserve University showed that a stem cell-based therapy has promise for treating resistant and chronic lung infections with non-tuberculosis mycobacteria. Using a human cell line and a mouse model, the research team demonstrated that human marrow‐derived mesenchymal stem cells (MSCs) have antimicrobial and anti-inflammatory activity against…
Published on July 6, 2020
Once an ecosystem is disturbed, restoring it can be difficult. And when the disturbed ecosystem is a patient’s microbiome, restoring the patient to health can be even more difficult. Just one ecosystem element that proliferates or diminishes beyond bounds may throw multiple elements into disarray, creating a dysbiosis that resists…