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Researchers Discover Motor Neuron Toxin Release by Astrocytes in Amyotrophic Lateral Sclerosis

A new mouse study demonstrates how astrocytes release an inorganic polyphosphate (polyP) in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) that contributes to motor neuron death.
C. elegans

Scientists Discover Probiotic That Prevents Neurodegeneration in ALS Model

A new study at Canada’s CHUM Research Centre (CRCHUM) has found that the probiotic bacterium Lacticaseibacillus rhamnosus HA-114 prevents neurodegeneration in C. elegans, a model used for the study of amyotrophic lateral sclerosis (ALS).

Treatment with Own Cells Offers Degenerative Disease Hope

Enhancing the number and function of a patient’s own regulatory T-lymphocytes may slow progression of the degenerative disease amyotrophic lateral sclerosis (ALS), an early study suggests.
Protoplasmic and fibrous astrocytes, illustration

Muscle Biopsy TDP-43-Based Test for ALS Promising

Muscle biopsies tested for phosphorylated transactive response DNA-binding protein 43–positive axons in intramuscular nerve bundles can distinguish amyotrophic lateral sclerosis patients.
Protoplasmic and fibrous astrocytes, illustration

ALS and Frontotemporal Dementia Both Linked to Common Variants

Adult-onset neurodegenerative amyotrophic lateral sclerosis and frontotemporal dementia are both worsened by genetic variants in a single gene, UNC13A.
ALS patient at his room

Machine Learning Approach Gives New Insight Into ALS Genetics

A new machine-learning based tool will help us to understand and profile the genetic basis of amyotrophic lateral sclerosis, according to a research team from Stanford and the University of Sheffield.
Mini-brain organoids showing cortex-like structures

Researchers Find Pointers for New ALS Treatments from Mini Brains in the Lab

Insights from a mini brain model developed at the University of Cambridge could help develop better therapeutics for amyotrophic lateral sclerosis and other similarly devastating neurodegenerative conditions.
ALS patient at his room

Biogen’s ALS Candidate Tofersen Misses Endpoint in Phase III Trial

The antisense drug missed its primary endpoint in a Phase III trial in people with superoxide dismutase 1 (SOD1) amyotrophic lateral sclerosis (ALS)—but showed what the principal investigator called encouraging multiple secondary and exploratory measures of biologic activity and clinical function.
Herpes Simplex Virus Infection

More Evidence Found of Connection Between HSV-1 and Neurodegenerative Diseases

In a “first of its kind” study, researchers at the University of Illinois, Chicago (UIC) have presented information suggesting a new potential direct link between herpes simplex virus type 1 (HSV-1) and neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and glaucoma.
Kiana Aran

Single-Point Mutations Detected by CRISPR-Based Transistor

The ability of the SNP-chip to identify single nucleotide polymorphisms (SNPs) was illustrated in two genetic diseases: amyotrophic lateral sclerosis (ALS) and sickle cell disease (SCD).


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