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Researchers Discover Motor Neuron Toxin Release by Astrocytes in Amyotrophic Lateral Sclerosis
A new mouse study demonstrates how astrocytes release an inorganic polyphosphate (polyP) in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) that contributes to motor neuron death.
Scientists Discover Probiotic That Prevents Neurodegeneration in ALS Model
A new study at Canada’s CHUM Research Centre (CRCHUM) has found that the probiotic bacterium Lacticaseibacillus rhamnosus HA-114 prevents neurodegeneration in C. elegans, a model used for the study of amyotrophic lateral sclerosis (ALS).
Treatment with Own Cells Offers Degenerative Disease Hope
Enhancing the number and function of a patient’s own regulatory T-lymphocytes may slow progression of the degenerative disease amyotrophic lateral sclerosis (ALS), an early study suggests.
Muscle Biopsy TDP-43-Based Test for ALS Promising
Muscle biopsies tested for phosphorylated transactive response DNA-binding protein 43–positive axons in intramuscular nerve bundles can distinguish amyotrophic lateral sclerosis patients.
ALS and Frontotemporal Dementia Both Linked to Common Variants
Adult-onset neurodegenerative amyotrophic lateral sclerosis and frontotemporal dementia are both worsened by genetic variants in a single gene, UNC13A.
Machine Learning Approach Gives New Insight Into ALS Genetics
A new machine-learning based tool will help us to understand and profile the genetic basis of amyotrophic lateral sclerosis, according to a research team from Stanford and the University of Sheffield.
Researchers Find Pointers for New ALS Treatments from Mini Brains in the Lab
Insights from a mini brain model developed at the University of Cambridge could help develop better therapeutics for amyotrophic lateral sclerosis and other similarly devastating neurodegenerative conditions.
Biogen’s ALS Candidate Tofersen Misses Endpoint in Phase III Trial
The antisense drug missed its primary endpoint in a Phase III trial in people with superoxide dismutase 1 (SOD1) amyotrophic lateral sclerosis (ALS)—but showed what the principal investigator called encouraging multiple secondary and exploratory measures of biologic activity and clinical function.
More Evidence Found of Connection Between HSV-1 and Neurodegenerative Diseases
In a “first of its kind” study, researchers at the University of Illinois, Chicago (UIC) have presented information suggesting a new potential direct link between herpes simplex virus type 1 (HSV-1) and neurodegenerative diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), and glaucoma.
Single-Point Mutations Detected by CRISPR-Based Transistor
The ability of the SNP-chip to identify single nucleotide polymorphisms (SNPs) was illustrated in two genetic diseases: amyotrophic lateral sclerosis (ALS) and sickle cell disease (SCD).